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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis.

The stability of wild-type p53 is critical for its apoptotic function. In some cancers, wild-type p53 is inactivated by interaction with viral and cellular proteins, and restoration of its activity has therapeutic potential. Here, we identify homeobox Msx1 as a p53-interacting protein and show its novel function as a p53 regulator. Overexpression of homeobox Msx1 induced apoptosis of cancer cells harboring nonfunctional wild-type p53 and suppressed growth of human tumor xenografts in nude mice. The homeodomain of Msx1 functions as a protein-protein interacting motif rather than a DNA-binding domain and is essential for stabilization, nuclear accumulation, and apoptotic function of wild-type p53. The identification of a novel function of Msx1 as a p53 regulator may open new avenues for developing improved molecular therapies for tumors with a nonmutational p53 inactivation mechanism.[1]


  1. Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis. Park, K., Kim, K., Rho, S.B., Choi, K., Kim, D., Oh, S.H., Park, J., Lee, S.H., Lee, J.H. Cancer Res. (2005) [Pubmed]
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