Gene Review:
LBX1 - ladybird homeobox 1
Homo sapiens
Synonyms:
HPX-6, HPX6, LBX1H, Ladybird homeobox protein homolog 1, Transcription factor LBX1, ...
- Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. Jagla, K., Dollé, P., Mattei, M.G., Jagla, T., Schuhbaur, B., Dretzen, G., Bellard, F., Bellard, M. Mech. Dev. (1995)
- HOXD3-overexpression increases integrin alphavbeta3 expression and deprives E-cadherin while it enhances cell motility in A549 cells. Ohta, H., Hamada, J., Tada, M., Aoyama, T., Furuuchi, K., Takahashi, Y., Totsuka, Y., Moriuchi, T. Clin. Exp. Metastasis (2006)
- Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene. Glaser, T., Walton, D.S., Maas, R.L. Nat. Genet. (1992)
- Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Hiroi, Y., Kudoh, S., Monzen, K., Ikeda, Y., Yazaki, Y., Nagai, R., Komuro, I. Nat. Genet. (2001)
- Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Dattani, M.T., Martinez-Barbera, J.P., Thomas, P.Q., Brickman, J.M., Gupta, R., Mårtensson, I.L., Toresson, H., Fox, M., Wales, J.K., Hindmarsh, P.C., Krauss, S., Beddington, R.S., Robinson, I.C. Nat. Genet. (1998)
- Decreased thalamic expression of the homeobox gene DLX1 in psychosis. Kromkamp, M., Uylings, H.B., Smidt, M.P., Hellemons, A.J., Burbach, J.P., Kahn, R.S. Arch. Gen. Psychiatry (2003)
- The DiGeorge syndrome minimal critical region contains a goosecoid-like (GSCL) homeobox gene that is expressed early in human development. Gottlieb, S., Emanuel, B.S., Driscoll, D.A., Sellinger, B., Wang, Z., Roe, B., Budarf, M.L. Am. J. Hum. Genet. (1997)
- Transcriptional control of the cell cycle in mammary gland development and tumorigenesis. Coletta, R.D., Jedlicka, P., Gutierrez-Hartmann, A., Ford, H.L. Journal of mammary gland biology and neoplasia. (2004)
- Similarities in genetic mental retardation and neuroteratogenic syndromes. Adams, J. Pharmacol. Biochem. Behav. (1996)
- The roles of retinoids in vertebrate development. Means, A.L., Gudas, L.J. Annu. Rev. Biochem. (1995)
- Homeobox galore: when reproduction goes RHOX and roll. Hogeveen, K.N., Sassone-Corsi, P. Cell (2005)
- Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Aoki, K., Tamai, Y., Horiike, S., Oshima, M., Taketo, M.M. Nat. Genet. (2003)
- Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome. Amiel, J., Laudier, B., Attié-Bitach, T., Trang, H., de Pontual, L., Gener, B., Trochet, D., Etchevers, H., Ray, P., Simonneau, M., Vekemans, M., Munnich, A., Gaultier, C., Lyonnet, S. Nat. Genet. (2003)
- Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Simeone, A., Acampora, D., Arcioni, L., Andrews, P.W., Boncinelli, E., Mavilio, F. Nature (1990)
- Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells. Buettner, R., Yim, S.O., Hong, Y.S., Boncinelli, E., Tainsky, M.A. Mol. Cell. Biol. (1991)
- Gene expression profiling of human sarcomas: insights into sarcoma biology. Baird, K., Davis, S., Antonescu, C.R., Harper, U.L., Walker, R.L., Chen, Y., Glatfelter, A.A., Duray, P.H., Meltzer, P.S. Cancer Res. (2005)
- A role for the homeobox protein Distal-less 3 in the activation of the glycoprotein hormone alpha subunit gene in choriocarcinoma cells. Roberson, M.S., Meermann, S., Morasso, M.I., Mulvaney-Musa, J.M., Zhang, T. J. Biol. Chem. (2001)
- A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. He, W.W., Sciavolino, P.J., Wing, J., Augustus, M., Hudson, P., Meissner, P.S., Curtis, R.T., Shell, B.K., Bostwick, D.G., Tindall, D.J., Gelmann, E.P., Abate-Shen, C., Carter, K.C. Genomics (1997)
- Pax6 Regulation in Retinal Cells by CCCTC Binding Factor. Li, T., Lu, Z., Lu, L. Invest. Ophthalmol. Vis. Sci. (2006)
- Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3. Su, X., Drabkin, H., Clappier, E., Morgado, E., Busson, M., Romana, S., Soulier, J., Berger, R., Bernard, O.A., Lavau, C. Genes Chromosomes Cancer (2006)
- Deletions of 2q14 that include the homeobox engrailed 1 (EN1) transcription factor are compatible with a normal phenotype. Barber, J.C., Maloney, V.K., Bewes, B., Wakeling, E. Eur. J. Hum. Genet. (2006)
- Identification of homeobox genes expressed in human haemopoietic progenitor cells. Moretti, P., Simmons, P., Thomas, P., Haylock, D., Rathjen, P., Vadas, M., D'Andrea, R. Gene (1994)
- Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae. McGinnis, N., Kuziora, M.A., McGinnis, W. Cell (1990)
- Nuclear Factor Y Drives Basal Transcription of the Human TLX3, a Gene Overexpressed in T-Cell Acute Lymphocytic Leukemia. Borghini, S., Vargiolu, M., Di Duca, M., Ravazzolo, R., Ceccherini, I. Mol. Cancer Res. (2006)
- Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. Self, M., Lagutin, O.V., Bowling, B., Hendrix, J., Cai, Y., Dressler, G.R., Oliver, G. EMBO J. (2006)
- Effect of CTCF-binding motif on regulation of PAX6 transcription. Wu, D., Li, T., Lu, Z., Dai, W., Xu, M., Lu, L. Invest. Ophthalmol. Vis. Sci. (2006)
- Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Freund, C.L., Gregory-Evans, C.Y., Furukawa, T., Papaioannou, M., Looser, J., Ploder, L., Bellingham, J., Ng, D., Herbrick, J.A., Duncan, A., Scherer, S.W., Tsui, L.C., Loutradis-Anagnostou, A., Jacobson, S.G., Cepko, C.L., Bhattacharya, S.S., McInnes, R.R. Cell (1997)
- Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Furukawa, T., Morrow, E.M., Li, T., Davis, F.C., Cepko, C.L. Nat. Genet. (1999)
- Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. da Silva Xavier, G., Rutter, J., Rutter, G.A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain. Baier, L.J., Hannibal, M.C., Hanley, E.W., Nabel, G.J. Blood (1991)
- Mutation in the RIEG1 gene in patients with iridogoniodysgenesis syndrome. Kulak, S.C., Kozlowski, K., Semina, E.V., Pearce, W.G., Walter, M.A. Hum. Mol. Genet. (1998)
- Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers. Voeller, H.J., Augustus, M., Madike, V., Bova, G.S., Carter, K.C., Gelmann, E.P. Cancer Res. (1997)
- Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10. Bae, N.S., Swanson, M.J., Vassilev, A., Howard, B.H. J. Biochem. (2004)
- Down-regulation of homeobox gene GBX2 expression inhibits human prostate cancer clonogenic ability and tumorigenicity. Gao, A.C., Lou, W., Isaacs, J.T. Cancer Res. (1998)
- Pathogenesis of pre-neoplastic lesions of the stomach: targets for prevention. Leung, W.K., Sung, J.J. Digestive diseases (Basel, Switzerland) (2004)
- The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Dear, T.N., Sanchez-Garcia, I., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis. Park, K., Kim, K., Rho, S.B., Choi, K., Kim, D., Oh, S.H., Park, J., Lee, S.H., Lee, J.H. Cancer Res. (2005)
- HOXC13 is involved in the regulation of human hair keratin gene expression. Jave-Suarez, L.F., Winter, H., Langbein, L., Rogers, M.A., Schweizer, J. J. Biol. Chem. (2002)
- Transcriptional repression of the cystic fibrosis transmembrane conductance regulator gene, mediated by CCAAT displacement protein/cut homolog, is associated with histone deacetylation. Li, S., Moy, L., Pittman, N., Shue, G., Aufiero, B., Neufeld, E.J., LeLeiko, N.S., Walsh, M.J. J. Biol. Chem. (1999)
- A complex containing PBX2 contributes to activation of the proto-oncogene HOX11. Brake, R.L., Kees, U.R., Watt, P.M. Biochem. Biophys. Res. Commun. (2002)
- Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). Chase, A., Reiter, A., Burci, L., Cazzaniga, G., Biondi, A., Pickard, J., Roberts, I.A., Goldman, J.M., Cross, N.C. Blood (1999)
- Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Zeisig, B.B., Milne, T., García-Cuéllar, M.P., Schreiner, S., Martin, M.E., Fuchs, U., Borkhardt, A., Chanda, S.K., Walker, J., Soden, R., Hess, J.L., Slany, R.K. Mol. Cell. Biol. (2004)
- Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Waeber, G., Thompson, N., Nicod, P., Bonny, C. Mol. Endocrinol. (1996)
- A vasoactive intestinal peptide receptor analog alters the expression of homeobox genes. Steingart, R.A., Heldenberg, E., Pinhasov, A., Brenneman, D.E., Fridkin, M., Gozes, I. Life Sci. (2002)
- A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24. de Mollerat, X.J., Gurrieri, F., Morgan, C.T., Sangiorgi, E., Everman, D.B., Gaspari, P., Amiel, J., Bamshad, M.J., Lyle, R., Blouin, J.L., Allanson, J.E., Le Marec, B., Wilson, M., Braverman, N.E., Radhakrishna, U., Delozier-Blanchet, C., Abbott, A., Elghouzzi, V., Antonarakis, S., Stevenson, R.E., Munnich, A., Neri, G., Schwartz, C.E. Hum. Mol. Genet. (2003)
- Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects. Mavrogiannis, L.A., Antonopoulou, I., Baxová, A., Kutílek, S., Kim, C.A., Sugayama, S.M., Salamanca, A., Wall, S.A., Morriss-Kay, G.M., Wilkie, A.O. Nat. Genet. (2001)
- A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD. Semina, E.V., Ferrell, R.E., Mintz-Hittner, H.A., Bitoun, P., Alward, W.L., Reiter, R.S., Funkhauser, C., Daack-Hirsch, S., Murray, J.C. Nat. Genet. (1998)
- High Expression of the ETS Transcription Factor ERG Predicts Adverse Outcome in Acute T-Lymphoblastic Leukemia in Adults. Baldus, C.D., Burmeister, T., Martus, P., Schwartz, S., G??kbuget, N., Bloomfield, C.D., Hoelzer, D., Thiel, E., Hofmann, W.K. J. Clin. Oncol. (2006)
- Expression pattern of the homeodomain transcription factor Pitx2 during muscle development. Shih, H.P., Gross, M.K., Kioussi, C. Gene Expr. Patterns (2007)
- Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Chisaka, O., Capecchi, M.R. Nature (1991)
- Zmhox1a, the product of a novel maize homeobox gene, interacts with the Shrunken 26 bp feedback control element. Bellmann, R., Werr, W. EMBO J. (1992)
- Sequence analysis and expression patterns divide the maize knotted1-like homeobox genes into two classes. Kerstetter, R., Vollbrecht, E., Lowe, B., Veit, B., Yamaguchi, J., Hake, S. Plant Cell (1994)