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Kampman, K.M. et al.

Kampman, Leiderman, Holmes, LoCastro, Bloch, Reid, Shoptaw, Montgomery, Winhusen, Somoza, Ciraulo, Elkashef, Vocci,

Cocaine Rapid Efficacy Screening Trials (CREST): lessons learned.

AIMS: The Cocaine Rapid Efficacy Screening Trials (CREST) were designed by the National Institute on Drug Abuse Division of Treatment Research and Development (NIDA, DT R&D) to rapidly screen a number of medications potentially useful for the treatment of cocaine dependence. DESIGN: Each CREST trial was designed to compare several medications in a single trial against an unmatched placebo. The placebo group was included in each trial to avoid the nearly universal positive response to medications seen in open-label trials. In addition, a common set of procedures and outcome measures were employed throughout to increase comparability of results obtained from different trials and from different times. PARTICIPANTS: In all, 18 medications were screened in seven different trials, conducted in four different sites throughout the United States involving 398 cocaine-dependent patients. FINDINGS: Three medications were found to be promising enough to include in subsequent larger trials. Common statistical procedures for evaluating medications were developed to facilitate comparisons across sites and across time. A portion of the data were pooled and analyzed, which yielded some useful insights into cocaine dependence and its treatment. Finally, a review of individual trials together with the pooled analysis revealed several potential improvements for future screening trials. CONCLUSIONS: Overall, the CREST trials proved to be useful for rapidly screening medications for treatment of cocaine dependence, but several modifications in design should be made before this framework is applied further.[1]

References

Cocaine Rapid Efficacy Screening Trials (CREST): lessons learned. Kampman, K.M., Leiderman, D., Holmes, T., LoCastro, J., Bloch, D.A., Reid, M.S., Shoptaw, S., Montgomery, M.A., Winhusen, T.M., Somoza, E.C., Ciraulo, D.A., Elkashef, A., Vocci, F. Addiction (2005) [Pubmed]

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