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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Research

  • To determine research priorities in infectious diseases, the impact of infections on hospital care in the United States is estimated from the number of infectious diseases observed in hospitals that cooperate with the Center for Disease Control in surveillance of community-acquired and nosocomial infections [1].
  • Epidemiological observations and laboratory research have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of colon carcinogenesis by NSAIDs is mediated through the modulation of prostaglandin production by rate-limiting enzymes known as cyclooxygenases (COXs) [2].
  • PURPOSE: To review the preclinical and clinical studies relevant to the prognosis and prognostic associations of BRCA1- and BRCA2-associated breast carcinomas, with an emphasis on research methodology [3].
  • Furthermore, several lines of laboratory research suggest that dopamine agonists might protect dopaminergic neurons in PD and retard the rate of disease progression [4].
  • A unique strategy of sample blinding is introduced in this protocol, wherein both subject and control specimens are supplied to the research laboratory as coded samples, spiking blood from HIV seropositive volunteers matched for CD4 lymphocyte count with known but varying numbers of cells transduced with each vector [5].

Psychiatry related information on Research


High impact information on Research

  • Since that first report intense research activity has been directed towards determining the mechanism of action of the active atrial natriuretic polypeptides (ANP) found in these extracts [11].
  • The American kestrel as a laboratory research animal [12].
  • This trend should encourage reevaluation of research priorities and previously accepted standards for optimal fluoride use [13].
  • Current research activities on the characterization of CYP expression, function, and regulation in these tissues, as well as future research needs, are discussed [14].
  • Chloroquine is effective for prophylaxis only in Central America, the Caribbean, and parts of the Middle East. Few new drugs will be available in the near future because of reduced funding for antimalarial drug research and development; therefore, the usefulness of currently available drugs needs to be prolonged by rational use [15].

Chemical compound and disease context of Research


Biological context of Research


Anatomical context of Research


Associations of Research with chemical compounds


Gene context of Research


Analytical, diagnostic and therapeutic context of Research


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  5. A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Wong-Staal, F., Poeschla, E.M., Looney, D.J. Hum. Gene Ther. (1998) [Pubmed]
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  16. Toluidine red unheated serum test, a nontreponemal test for syphilis. Pettit, D.E., Larsen, S.A., Harbec, P.S., Feeley, J.C., Parham, C.E., Cruce, D.D., Hambie, E.A., Perryman, M.W. J. Clin. Microbiol. (1983) [Pubmed]
  17. Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Lebwohl, D., Canetta, R. Eur. J. Cancer (1998) [Pubmed]
  18. Medical reduction of stone risk in a network of treatment centers compared to a research clinic. Lingeman, J., Mardis, H., Kahnoski, R., Goldfarb, D.S., Lacy, S., Grasso, M., Scheinman, S.J., Parks, J.H., Asplin, J.R., Coe, F.L. J. Urol. (1998) [Pubmed]
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  21. L-glutamine stimulates jejunal sodium and chloride absorption in pig rotavirus enteritis. Rhoads, J.M., Keku, E.O., Quinn, J., Woosely, J., Lecce, J.G. Gastroenterology (1991) [Pubmed]
  22. An application of the revised CONSORT standards to FDA summary reports of recently approved antidepressants and antipsychotics. Khan, A., Khan, S.R., Leventhal, R.M., Krishnan, K.R., Gorman, J.M. Biol. Psychiatry (2002) [Pubmed]
  23. Highlights of the eighth international conference on carcinogenic/mutagenic N-substituted aryl compounds. Snyderwine, E.G., Sinha, R., Felton, J.S., Ferguson, L.R. Mutat. Res. (2002) [Pubmed]
  24. Relation of salivary cotinine to blood pressure in middle-aged cigarette smokers. Istvan, J.A., Lee, W.W., Buist, A.S., Connett, J.E. Am. Heart J. (1999) [Pubmed]
  25. Measurements of atmospheric mercury species at a coastal site in the Antarctic and over the south Atlantic Ocean during polar summer. Temme, C., Einax, J.W., Ebinghaus, R., Schroeder, W.H. Environ. Sci. Technol. (2003) [Pubmed]
  26. The cellular immunology of multiple sclerosis. Al-Omaishi, J., Bashir, R., Gendelman, H.E. J. Leukoc. Biol. (1999) [Pubmed]
  27. Langerhans cell histiocytosis. Egeler, R.M., D'Angio, G.J. J. Pediatr. (1995) [Pubmed]
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  29. The non-neuronal cholinergic system in the endothelium: evidence and possible pathobiological significance. Kirkpatrick, C.J., Bittinger, F., Unger, R.E., Kriegsmann, J., Kilbinger, H., Wessler, I. Jpn. J. Pharmacol. (2001) [Pubmed]
  30. Are recombinant human bone morphogenetic protein-7 and tobramycin compatible? An experiment in rats. Kawaguchi, A.T., Reddi, A.H., Olson, S.A., Yinger, K.E., Moehring, H.D. Journal of orthopaedic trauma. (2004) [Pubmed]
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  32. The long and winding road from the research laboratory to industrial applications of lactic acid bacteria. Pedersen, M.B., Iversen, S.L., Sørensen, K.I., Johansen, E. FEMS Microbiol. Rev. (2005) [Pubmed]
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  36. Status of aromatase inhibitors in relation to other breast cancer treatment modalities. Ragaz, J. Endocr. Relat. Cancer (1999) [Pubmed]
  37. Current advances in unraveling the function of the Werner syndrome protein. Ozgenc, A., Loeb, L.A. Mutat. Res. (2005) [Pubmed]
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