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Cui, N.Q. et al.

Cui, Zhang, Cui, Li, Chen, Wu,

Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones.

BACKGROUND: Hypersecretion of biliary cholesterol is believed to be one of the important causes of lithogenic bile. Sterol carrier protein-2(SCP2) participates in cholesterol trafficking and metabolism and may play a key role in cholesterol gallstone formation. This study was undertaken to investigate the expression of liver SCP2 mRNA in patients with cholesterol gallstone and those patients with non-cholesterol gallstone. METHODS: The expression of liver SCP2mRNA was studied in 36 patients with cholesterol gallstone and 30 patients with non-cholesterol gallstone by reverse transcription-polymerase chain reaction (RT-PCR). RESULT: The expression of SCP2 mRNA was increased more significantly in patients with cholesterol gallstone than in patients with non-cholesterol gallstone. CONCLUSION: The SCP2 gene was overexpressed in patients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone.[1]

References

Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones. Cui, N.Q., Zhang, S.K., Cui, Y.F., Li, D.H., Chen, C., Wu, X.Z. HBPD INT (2005) [Pubmed]

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