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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Role of nociceptin/orphanin FQ ( Noc/oFQ) in murine experimental colitis.

Nociceptin/orphanin ( Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.[1]


  1. Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis. Kato, S., Tsuzuki, Y., Hokari, R., Okada, Y., Miyazaki, J., Matsuzaki, K., Iwai, A., Kawaguchi, A., Nagao, S., Itoh, K., Suzuki, H., Nabeshima, T., Miura, S. J. Neuroimmunol. (2005) [Pubmed]
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