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Gene Review

Madcam1  -  mucosal vascular addressin cell adhesion...

Mus musculus

Synonyms: AV211525, MAdCAM-1, Mucosal addressin cell adhesion molecule 1, mMAdCAM-1
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Disease relevance of Madcam1


Psychiatry related information on Madcam1


High impact information on Madcam1


Chemical compound and disease context of Madcam1


Biological context of Madcam1


Anatomical context of Madcam1


Associations of Madcam1 with chemical compounds


Physical interactions of Madcam1

  • We have modeled peptides based on the predicted structure of the alpha 4 beta 7 integrin binding motif on MAdCAM-1 and are able to show specific and selective blocking of cell binding [18].

Co-localisations of Madcam1


Regulatory relationships of Madcam1


Other interactions of Madcam1

  • Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteins [11].
  • Interestingly, VCAM-1 and MAdCAM-1 were not expressed in the GTs of uninfected mice but were temporarily induced following infection, indicating that expression of endothelial ligands in the GT are regulated by chlamydial infection [22].
  • In the present paper, it is shown that an antibody directed against MAdCAM-1, the preferential ligand for alpha4beta7, effectively prevented the development of a progressive, non-remitting, form of EAE, actively induced by injection of myelin oligodendrocyte glycoprotein peptide (MOG(35-55)) autoantigen [3].
  • Comparison of MAdCAM-1 expression on the bEnd.3 cells was made to the expression of adhesion molecules ICAM-1 and VCAM-1 [13].
  • Our data suggest a role for a homeodomain factor in establishing the developmental and positional cues in endothelia that regulate leukocyte homing through local control of cellular adhesion and identify MAdCAM-1 as a candidate target gene of Nkx2-3 [19].

Analytical, diagnostic and therapeutic context of Madcam1


  1. Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation. Connor, E.M., Eppihimer, M.J., Morise, Z., Granger, D.N., Grisham, M.B. J. Leukoc. Biol. (1999) [Pubmed]
  2. Increased expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and lymphocyte recruitment in murine gastritis induced by Helicobacter pylori. Hatanaka, K., Hokari, R., Matsuzaki, K., Kato, S., Kawaguchi, A., Nagao, S., Suzuki, H., Miyazaki, K., Sekizuka, E., Nagata, H., Ishii, H., Miura, S. Clin. Exp. Immunol. (2002) [Pubmed]
  3. Prevention of a chronic progressive form of experimental autoimmune encephalomyelitis by an antibody against mucosal addressin cell adhesion molecule-1, given early in the course of disease progression. Kanwar, J.R., Kanwar, R.K., Wang, D., Krissansen, G.W. Immunol. Cell Biol. (2000) [Pubmed]
  4. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Berlin, C., Berg, E.L., Briskin, M.J., Andrew, D.P., Kilshaw, P.J., Holzmann, B., Weissman, I.L., Hamann, A., Butcher, E.C. Cell (1993) [Pubmed]
  5. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Fernekorn, U., Butcher, E.C., Behrends, J., Hartz, S., Kruse, A. Eur. J. Immunol. (2004) [Pubmed]
  6. alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Berlin, C., Bargatze, R.F., Campbell, J.J., von Andrian, U.H., Szabo, M.C., Hasslen, S.R., Nelson, R.D., Berg, E.L., Erlandsen, S.L., Butcher, E.C. Cell (1995) [Pubmed]
  7. Glucocorticoids and IL-10, but not 6-MP, 5-ASA or sulfasalazine block endothelial expression of MAdCAM-1: implications for inflammatory bowel disease therapy. Oshima, T., Pavlick, K., Grisham, M.B., Jordan, P., Manas, K., Joh, T., Itoh, M., Alexander, J.S. Aliment. Pharmacol. Ther. (2001) [Pubmed]
  8. The small GTP-binding proteins Rho and Rac induce T cell adhesion to the mucosal addressin MAdCAM-1 in a hierarchical fashion. Zhang, W.V., Yang, Y., Berg, R.W., Leung, E., Krissansen, G.W. Eur. J. Immunol. (1999) [Pubmed]
  9. Antisense therapy of MAdCAM-1 for trinitrobenzenesulfonic acid-induced murine colitis. Goto, A., Arimura, Y., Shinomura, Y., Imai, K., Hinoda, Y. Inflamm. Bowel Dis. (2006) [Pubmed]
  10. Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice. Campbell, P.K., Waymire, K.G., Heier, R.L., Sharer, C., Day, D.E., Reimann, H., Jaje, J.M., Friedrich, G.A., Burmeister, M., Bartness, T.J., Russell, L.D., Young, L.J., Zimmer, M., Jenne, D.E., MacGregor, G.R. Genetics (2002) [Pubmed]
  11. Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteins. Takeuchi, M., Baichwal, V.R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  12. Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation. Katayama, Y., Hidalgo, A., Peired, A., Frenette, P.S. Blood (2004) [Pubmed]
  13. The Peyer's patch high endothelial receptor for lymphocytes, the mucosal vascular addressin, is induced on a murine endothelial cell line by tumor necrosis factor-alpha and IL-1. Sikorski, E.E., Hallmann, R., Berg, E.L., Butcher, E.C. J. Immunol. (1993) [Pubmed]
  14. TNF-alpha -induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent. Sasaki, M., Ostanin, D., Elrod, J.W., Oshima, T., Jordan, P., Itoh, M., Joh, T., Minagar, A., Alexander, J.S. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  15. Selectin, platelet plays a critical role in granulocyte access to the pregnant mouse uterus under physiological and pathological conditions. Fernekorn, U., Butcher, E.C., Behrends, J., Karsten, C.M., Röbke, A., Schulze, T.J., Kirchner, H., Kruse, A. Biol. Reprod. (2007) [Pubmed]
  16. Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha. Sasaki, M., Jordan, P., Welbourne, T., Minagar, A., Joh, T., Itoh, M., Elrod, J.W., Alexander, J.S. BMC Physiol. (2005) [Pubmed]
  17. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Berg, E.L., McEvoy, L.M., Berlin, C., Bargatze, R.F., Butcher, E.C. Nature (1993) [Pubmed]
  18. Mucosal addressin cell adhesion molecule-1: a structural and functional analysis demarcates the integrin binding motif. Viney, J.L., Jones, S., Chiu, H.H., Lagrimas, B., Renz, M.E., Presta, L.G., Jackson, D., Hillan, K.J., Lew, S., Fong, S. J. Immunol. (1996) [Pubmed]
  19. Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Wang, C.C., Biben, C., Robb, L., Nassir, F., Barnett, L., Davidson, N.O., Koentgen, F., Tarlinton, D., Harvey, R.P. Dev. Biol. (2000) [Pubmed]
  20. CXCL13 is an arrest chemokine for B cells in high endothelial venules. Kanemitsu, N., Ebisuno, Y., Tanaka, T., Otani, K., Hayasaka, H., Kaisho, T., Akira, S., Katagiri, K., Kinashi, T., Fujita, N., Tsuruo, T., Miyasaka, M. Blood (2005) [Pubmed]
  21. MAdCAM-1 expressing sacral lymph node in the lymphotoxin beta-deficient mouse provides a site for immune generation following vaginal herpes simplex virus-2 infection. Soderberg, K.A., Linehan, M.M., Ruddle, N.H., Iwasaki, A. J. Immunol. (2004) [Pubmed]
  22. Identification of homing receptors that mediate the recruitment of CD4 T cells to the genital tract following intravaginal infection with Chlamydia trachomatis. Kelly, K.A., Rank, R.G. Infect. Immun. (1997) [Pubmed]
  23. Spatial heterogeneity of TNF-alpha-induced T cell migration to colonic mucosa is mediated by MAdCAM-1 and VCAM-1. Watanabe, C., Miura, S., Hokari, R., Teramoto, K., Ogino, T., Komoto, S., Hara, Y., Koseki, S., Tsuzuki, Y., Nagata, H., Granger, D.N., Ishii, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  24. ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Steffen, B.J., Breier, G., Butcher, E.C., Schulz, M., Engelhardt, B. Am. J. Pathol. (1996) [Pubmed]
  25. Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells. Picarella, D., Hurlbut, P., Rottman, J., Shi, X., Butcher, E., Ringler, D.J. J. Immunol. (1997) [Pubmed]
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