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Methylmalonic acid--an endogenous toxin?

Methylmalonic acid was previously considered as major neurotoxin in methylmalonic acidurias. In contrast, recent studies support the notion that other metabolites deriving from propionyl-coenzyme A, inducing synergistic inhibition of mitochondrial energy metabolism, are more important than methylmalonic acid to understand the neuropathogenesis of this disease. However, it is not yet known whether methylmalonic acid is involved in the induction of other organ manifestations in this disease, such as chronic renal failure.[1]

References

  1. Methylmalonic acid--an endogenous toxin? Kölker, S., Okun, J.G. Cell. Mol. Life Sci. (2005) [Pubmed]
 
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