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Chemical Compound Review

Methylmalonic acid     2-methylpropanedioic acid

Synonyms: Isosuccinate, methylmalons, methylmalonate, M54058_ALDRICH, ACMC-209kuv, ...
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Disease relevance of Methylmalonic acid


Psychiatry related information on Methylmalonic acid


High impact information on Methylmalonic acid


Chemical compound and disease context of Methylmalonic acid


Biological context of Methylmalonic acid


Anatomical context of Methylmalonic acid


Associations of Methylmalonic acid with other chemical compounds


Gene context of Methylmalonic acid


Analytical, diagnostic and therapeutic context of Methylmalonic acid


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  6. Ammonia potentiates methylmalonic acid-induced convulsions and TBARS production. Marisco, P.d.a. .C., Ribeiro, M.C., Bonini, J.S., Lima, T.T., Mann, K.C., Brenner, G.M., Dutra-Filho, C.S., Mello, C.F. Exp. Neurol. (2003) [Pubmed]
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  12. Methylmalonic aciduria without vitamin B12 deficiency in an adult sibship. Giorgio, A.J., Trowbridge, M., Boone, A.W., Patten, R.S. N. Engl. J. Med. (1976) [Pubmed]
  13. Prenatal therapy of a patient with vitamin-B12-responsive methylmalonic acidemia. Ampola, M.G., Mahoney, M.J., Nakamura, E., Tanaka, K. N. Engl. J. Med. (1975) [Pubmed]
  14. Elevated methylmalonic acid and total homocysteine levels show high prevalence of vitamin B12 deficiency after gastric surgery. Sumner, A.E., Chin, M.M., Abrahm, J.L., Berry, G.T., Gracely, E.J., Allen, R.H., Stabler, S.P. Ann. Intern. Med. (1996) [Pubmed]
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  20. Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies. Hølleland, G., Schneede, J., Ueland, P.M., Lund, P.K., Refsum, H., Sandberg, S. Clin. Chem. (1999) [Pubmed]
  21. Diazoxide protects against methylmalonate-induced neuronal toxicity. Kowaltowski, A.J., Maciel, E.N., Fornazari, M., Castilho, R.F. Exp. Neurol. (2006) [Pubmed]
  22. Cerebrospinal fluid methylmalonic acid levels in normal subjects and patients with cobalamin deficiency. Stabler, S.P., Allen, R.H., Barrett, R.E., Savage, D.G., Lindenbaum, J. Neurology (1991) [Pubmed]
  23. Urinary methylmalonic acid excretion in infants fed formula or human milk. Specker, B.L., Brazerol, W., Ho, M.L., Norman, E.J. Am. J. Clin. Nutr. (1990) [Pubmed]
  24. Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+,K+-ATPase activity in the rat striatum and cerebral cortex. Malfatti, C.R., Royes, L.F., Francescato, L., Sanabria, E.R., Rubin, M.A., Cavalheiro, E.A., Mello, C.F. Epilepsia (2003) [Pubmed]
  25. Inhibition of bone marrow stem cell growth in vitro by methylmalonic acid: a mechanism for pancytopenia in a patient with methylmalonic acidemia. Inoue, S., Krieger, I., Sarnaik, A., Ravindranath, Y., Fracassa, M., Ottenbreit, M.J. Pediatr. Res. (1981) [Pubmed]
  26. Applicability of an enzymatic quantitation of methylmalonic, propionic, and acetic acids in normal and megaloblastic states. Frenkel, E.P., Kitchens, R.L. Blood (1977) [Pubmed]
  27. The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth. Obeid, R., Morkbak, A.L., Munz, W., Nexo, E., Herrmann, W. Clin. Chem. (2006) [Pubmed]
  28. Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid. Obeid, R., Kostopoulos, P., Knapp, J.P., Kasoha, M., Becker, G., Fassbender, K., Herrmann, W. Clin. Chem. (2007) [Pubmed]
  29. Vitamin B6 level is associated with symptoms of depression. Hvas, A.M., Juul, S., Bech, P., Nexø, E. Psychotherapy and psychosomatics. (2004) [Pubmed]
  30. Methylmalonic acid reduces the in vitro phosphorylation of cytoskeletal proteins in the cerebral cortex of rats. De Mattos-Dutra, A., De Freitas, M.S., Schröder, N., Zilles, A.C., Wajner, M., Pessoa-Pureur, R. Brain Res. (1997) [Pubmed]
  31. Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: Evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Chandler, R.J., Aswani, V., Tsai, M.S., Falk, M., Wehrli, N., Stabler, S., Allen, R., Sedensky, M., Kazazian, H.H., Venditti, C.P. Mol. Genet. Metab. (2006) [Pubmed]
  32. In vitro and in vivo inactivation of transcobalamin II receptor by its antiserum. Bose, S., Komorowski, R., Seetharam, S., Gilfix, B., Rosenblatt, D.S., Seetharam, B. J. Biol. Chem. (1996) [Pubmed]
  33. Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing. Solomon, L.R. Blood (2005) [Pubmed]
  34. Vitamin B12 deficiency in the elderly. Baik, H.W., Russell, R.M. Annu. Rev. Nutr. (1999) [Pubmed]
  35. Screening elderly populations for cobalamin (vitamin B12) deficiency using the urinary methylmalonic acid assay by gas chromatography mass spectrometry. Norman, E.J., Morrison, J.A. Am. J. Med. (1993) [Pubmed]
  36. Automated assay of methylmalonic acid in serum and urine by derivatization with 1-pyrenyldiazomethane, liquid chromatography, and fluorescence detection. Schneede, J., Ueland, P.M. Clin. Chem. (1993) [Pubmed]
  37. Application of capillary electrophoresis with laser-induced fluorescence detection for routine determination of methylmalonic acid in human serum. Schneede, J., Ueland, P.M. Anal. Chem. (1995) [Pubmed]
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