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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Expression of IL-2 receptor/p75 on lymphocytes from patients with rubella.

We analyzed the Interleukin-2 receptor (IL-2R) expression on fresh lymphocytes from three patients with rubella. Flow cytometric analysis demonstrated that lymphocytes from the patients expressed a considerable amount of IL-2R/p75 recognized by Mik-beta 1 monoclonal antibody (MoAb), although they did not react with anti-IL-2R/ p55 (CD25) MoAb. The expression of IL-2R/p75 reached a peak at the end of the acute phase of illness. Fresh lymphocytes from rubella patients showed a marked proliferative response to IL-2, which was completely inhibited by Mik-beta 1, indicating that their IL-2R is a functional receptor. The present data suggest that IL-2R/p75 expression is involved in the host immune response triggered by the rubella virus.[1]

References

  1. Expression of IL-2 receptor/p75 on lymphocytes from patients with rubella. Komada, Y., Oitani, K., Zhou, Y.W., Zhang, S.L., Sakurai, M. Acta paediatrica Japonica; Overseas edition. (1992) [Pubmed]
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