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MeSH Review

Rubella

 
 
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Disease relevance of Rubella

 

Psychiatry related information on Rubella

 

High impact information on Rubella

  • In the children with systemic-onset juvenile rheumatoid arthritis, only peripheral blood was examined, and of the five samples analyzed, one was shown to have rubella virus [7].
  • Letter: Congenital rubella and autistic behavior [8].
  • JAMA patient page. Rubella [9].
  • CONTEXT: A review by the Institute of Medicine found a possible relationship between rubella vaccination and chronic arthritis among women [5].
  • RESULTS: No significantly increased risk was associated with receipt of rubella vaccine for any outcome except for prevalence of carpal tunnel syndrome in vaccinated women at least 30 years old compared with seropositive, unvaccinated women (2.9% vs 1.4%; P=.03) [5].
 

Chemical compound and disease context of Rubella

  • The rubella virus E1 glycoprotein is arrested in a novel post-ER, pre-Golgi compartment [10].
  • Two hundred and forty-one children with congenital rubella (mean age 17.4 +/- 0.3 years; 65% black and hispanic) have been evaluated, 30 of whom already have diabetes and 17 of whom have borderline glucose tolerance [11].
  • Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus [12].
  • Additional tests based on similar technologies may aid in the diagnosis of viral hepatitis, measles, mumps, and rubella as well as in monitoring levels of therapeutic drugs such as theophylline [13].
  • A single-amino-acid substitution of a tyrosine residue in the rubella virus E1 cytoplasmic domain blocks virus release [14].
 

Biological context of Rubella

  • 636 women were enrolled and, after 90 women dropped out, 546 healthy women aged 18-41 years, who were rubella seronegative on routine screening were immunised parenterally with either monovalent live attenuated (RA27/3 strain) rubella vaccine (n = 270) or saline placebo (n = 276) in the postpartum period [15].
  • IgM serology for rubella and human parvovirus B19 [16].
  • Identification of calreticulin as a rubella virus RNA binding protein [17].
  • Calreticulin (CR) is a multifunctional, calcium-binding protein that has recently been shown to bind to and promote the replication of the rubella virus genome in mammalian cells [18].
  • These findings suggest that rubella virus has the potential to sensitize susceptible individuals for an autoimmune response to beta-cell Ag and identify one mechanism that may contribute to beta destruction in IDDM [19].
 

Anatomical context of Rubella

  • The immune response of peripheral blood lymphocytes to measles, rubella, parainfluenza types 1, 2, and 3 RNA virus antigens and to varicella-zoster and herpes virus type 1 DNA virus antigens was evaluated in 14 patients with rheumatoid arthritis (RA) and 14 matched controls by assessing 3H-thymidine incorporation [20].
  • CONCLUSION/INTERPRETATION: Cross-reactive glutamic acid decarboxylase and rubella virus determinants identified by T-cell clones were also recognised at high frequencies by general T-cell populations of Type I diabetic patients [12].
  • Translocation of rubella virus glycoprotein E1 into the endoplasmic reticulum [21].
  • IgM from human sera was absorbed into anti-human IgM-coated wells in plates and rubella-specific IgM was detected by adding rubella virus hemagglutinin and a small quantity of sheep erythrocytes [22].
  • These findings suggest that the lesions observed in late-onset rubella syndrome are partly due to CIC, and that suscepibility to infection can be related to a peripheral T and B lymphocyte disequilibrium [23].
 

Gene context of Rubella

 

Analytical, diagnostic and therapeutic context of Rubella

  • SETTING: Large health maintenance organization in northern California. PATIENTS: Women aged 15 to 59 years serotested for rubella during 1990 with continuous health plan membership for 2 years before and after the date of their serological test [5].
  • Three standard hemagglutination-inhibition (HAI) methods were compared with 11 commercially available diagnostic test kits for determination of immunity and serologic diagnosis of rubella using a panel of 100 sera [28].
  • Detection of rubella virus-specific immunoglobulin G in saliva by an amplification-based enzyme-linked immunosorbent assay using monoclonal antibody to fluorescein isothiocyanate [29].
  • Comparison of a new, rapid enzyme immunoassay with a latex agglutination test for qualitative detection of rubella antibodies [30].
  • Cell cultures inoculated directly with urine specimens showed greater nonspecificity by IP than by IF, but this activity could be abolished by pretreatment with sodium azide and peroxide; other methods tried for inactivating endogenous peroxidase activity destroyed rubella antigen as well [31].

References

  1. Editorial: Progressive rubella encephalitis. Johnson, R.T. N. Engl. J. Med. (1975) [Pubmed]
  2. Infection, thyroid disease, and autoimmunity. Tomer, Y., Davies, T.F. Endocr. Rev. (1993) [Pubmed]
  3. Antibody response following measles-mumps-rubella vaccine under conditions of customary use. Brunell, P.A., Weigle, K., Murphy, M.D., Shehab, Z., Cobb, E. JAMA (1983) [Pubmed]
  4. Adverse events associated with childhood vaccines other than pertussis and rubella. Summary of a report from the Institute of Medicine. Stratton, K.R., Howe, C.J., Johnston, R.B. JAMA (1994) [Pubmed]
  5. Risk of chronic arthropathy among women after rubella vaccination. Vaccine Safety Datalink Team. Ray, P., Black, S., Shinefield, H., Dillon, A., Schwalbe, J., Holmes, S., Hadler, S., Chen, R., Cochi, S., Wassilak, S. JAMA (1997) [Pubmed]
  6. Intrauterine rubella, head size, and intellect. Macfarlane, D.W., Boyd, R.D., Dodrill, C.B., Tufts, E. Pediatrics (1975) [Pubmed]
  7. Persistent rubella virus infection associated with chronic arthritis in children. Chantler, J.K., Tingle, A.J., Petty, R.E. N. Engl. J. Med. (1985) [Pubmed]
  8. Letter: Congenital rubella and autistic behavior. Swisher, C.N., Swisher, L. N. Engl. J. Med. (1975) [Pubmed]
  9. JAMA patient page. Rubella. Stevens, L.M. JAMA (2002) [Pubmed]
  10. The rubella virus E1 glycoprotein is arrested in a novel post-ER, pre-Golgi compartment. Hobman, T.C., Woodward, L., Farquhar, M.G. J. Cell Biol. (1992) [Pubmed]
  11. Congenital rubella syndrome as a model for type 1 (insulin-dependent) diabetes mellitus: increased prevalence of islet cell surface antibodies. Ginsberg-Fellner, F., Witt, M.E., Yagihashi, S., Dobersen, M.J., Taub, F., Fedun, B., McEvoy, R.C., Roman, S.H., Davies, R.G., Cooper, L.Z. Diabetologia (1984) [Pubmed]
  12. Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus. Ou, D., Mitchell, L.A., Metzger, D.L., Gillam, S., Tingle, A.J. Diabetologia (2000) [Pubmed]
  13. Future applications of oral fluid specimen technology. George, J.R., Fitchen, J.H. Am. J. Med. (1997) [Pubmed]
  14. A single-amino-acid substitution of a tyrosine residue in the rubella virus E1 cytoplasmic domain blocks virus release. Yao, J., Gillam, S. J. Virol. (2000) [Pubmed]
  15. Randomised double-blind placebo-controlled study on adverse effects of rubella immunisation in seronegative women. Tingle, A.J., Mitchell, L.A., Grace, M., Middleton, P., Mathias, R., MacWilliam, L., Chalmers, A. Lancet (1997) [Pubmed]
  16. IgM serology for rubella and human parvovirus B19. Cohen, B.J., Supran, E.M. Lancet (1987) [Pubmed]
  17. Identification of calreticulin as a rubella virus RNA binding protein. Singh, N.K., Atreya, C.D., Nakhasi, H.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen. Cheng, S.T., Nguyen, T.Q., Yang, Y.S., Capra, J.D., Sontheimer, R.D. J. Immunol. (1996) [Pubmed]
  19. Monoclonal antibody to rubella virus capsid protein recognizes a beta-cell antigen. Karounos, D.G., Wolinsky, J.S., Thomas, J.W. J. Immunol. (1993) [Pubmed]
  20. Hyporesponsiveness of lymphocytes to virus antigens in rheumatoid arthritis. Wolf, R.E. Arthritis Rheum. (1978) [Pubmed]
  21. Translocation of rubella virus glycoprotein E1 into the endoplasmic reticulum. Hobman, T.C., Shukin, R., Gillam, S. J. Virol. (1988) [Pubmed]
  22. Hemadsorption immunosorbent technique for determination of rubella immunoglobulin M antibody. van der Logt, J.T., van Loon, A.M., van der Veen, J. J. Clin. Microbiol. (1981) [Pubmed]
  23. Circulating immune complexes containing rubella antigens in late-onset rubella syndrome. Tardieu, M., Grospierre, B., Durandy, A., GAriscelli, C. J. Pediatr. (1980) [Pubmed]
  24. Expression of IL-2 receptor/p75 on lymphocytes from patients with rubella. Komada, Y., Oitani, K., Zhou, Y.W., Zhang, S.L., Sakurai, M. Acta paediatrica Japonica; Overseas edition. (1992) [Pubmed]
  25. Multiple sclerosis immune complexes: an analysis of component antigens and antibodies. Coyle, P.K., Procyk-Dougherty, Z. Ann. Neurol. (1984) [Pubmed]
  26. Selective tolerance to the E1 protein of rubella virus in congenital rubella syndrome. Mauracher, C.A., Mitchell, L.A., Tingle, A.J. J. Immunol. (1993) [Pubmed]
  27. Virus-specific and autoreactive T cell lines isolated from cerebrospinal fluid of a patient with chronic rubella panencephalitis. Martin, R., Marquardt, P., O'Shea, S., Borkenstein, M., Kreth, H.W. J. Neuroimmunol. (1989) [Pubmed]
  28. Evaluation of commercially available diagnostic test kits for rubella. Castellano, G.A., Madden, D.L., Hazzard, G.T., Cleghorn, C.S., Vails, D.V., Ley, A.C., Tzan, N.R., Sever, J.L. J. Infect. Dis. (1981) [Pubmed]
  29. Detection of rubella virus-specific immunoglobulin G in saliva by an amplification-based enzyme-linked immunosorbent assay using monoclonal antibody to fluorescein isothiocyanate. Vyse, A.J., Brown, D.W., Cohen, B.J., Samuel, R., Nokes, D.J. J. Clin. Microbiol. (1999) [Pubmed]
  30. Comparison of a new, rapid enzyme immunoassay with a latex agglutination test for qualitative detection of rubella antibodies. Ferraro, M.J., Kallas, W.M., Welch, K.P., Lau, A.Y. J. Clin. Microbiol. (1987) [Pubmed]
  31. Comparison of immunofluorescence and immunoperoxidase staining for identification of rubella virus isolates. Schmidt, N.J., Dennis, J., Lennette, E.H. J. Clin. Microbiol. (1978) [Pubmed]
 
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