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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

TEC-family kinases: regulators of T-helper-cell differentiation.

The TEC-family protein tyrosine kinases ITK, RLK and TEC have been identified as key components of T-cell-receptor signalling that contribute to the regulation of phospholipase C-gamma, the mobilization of Ca(2+) and the activation of mitogen-activated protein kinases. Recent data also show that TEC kinases contribute to T-cell-receptor-driven actin reorganization and cell polarization, which are required for productive T-cell activation. Functional studies have implicated TEC kinases as important mediators of pathways that control the differentiation of CD4(+) T helper cells. Here, we review studies of signalling pathways that involve TEC kinases and how these pathways might contribute to the regulation of T-helper-cell differentiation and function.[1]


  1. TEC-family kinases: regulators of T-helper-cell differentiation. Schwartzberg, P.L., Finkelstein, L.D., Readinger, J.A. Nat. Rev. Immunol. (2005) [Pubmed]
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