Disease relevance of TEC

• Grade 3-4 nail disorders, hand-foot syndrome and peripheral neuropathy occurred in 46%, 73% and 68% of patients with TEC, EC-->T and T-->EC, respectively [1].
• Twenty-seven patients experienced grade 4 toxicity: 26%, 40% and 18% with TEC, EC-->T and T-->EC, respectively, mainly neutropenia, but febrile neutropenia occurred only in 11%, 10% and 3% [1].
• Dose-dense adjuvant chemotherapy in node-positive breast cancer: docetaxel followed by epirubicin/cyclophosphamide (T/EC), or the reverse sequence (EC/T), every 2 weeks, versus docetaxel, epirubicin and cyclophosphamide (TEC) every 3 weeks. AERO B03 randomized phase II study [1].
• However, when used as a primary treatment, TEC may be associated with lower rates of distal embolization and myocardial infarction [2].

High impact information on TEC

• The role of Tec protein-tyrosine kinase in T cell signaling [3].
• SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase [4].
• The aim of this study was to investigate the mechanism potentially involved in TEC proangiogenic phenotype [5].
• We found that thrombospondin-1 (TSP-1), a potent physiological inhibitor of angiogenesis, was significantly reduced in TEC in respect to normal endothelial cells [5].
• As TEC were shown to display a basal upregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, we evaluated the possible regulation of TSP-1 by this pathway by using LY294002 and wortmannin, the PI3K inhibitors, and rapamycin, the mammalian target of rapamycin (mTOR) inhibitor [5].

Biological context of TEC

• In addition, downregulation of Akt activation in negative dominant Akt TEC enhanced TSP-1 expression and release [5].

Anatomical context of TEC

• Recent data also show that TEC kinases contribute to T-cell-receptor-driven actin reorganization and cell polarization, which are required for productive T-cell activation [6].
• Functional studies have implicated TEC kinases as important mediators of pathways that control the differentiation of CD4(+) T helper cells [6].
• However, newborns and adults did not differ with regard to the percentage of cells reacting with the Leulla, Leullc and TEC NK-1, monoclonal antibodies directed against the IgG Fc receptor of killer cells [7].
• umor-derived endothelial cells (TEC) display increased survival and angiogenic properties in respect to normal endothelial cells [5].

Associations of TEC with chemical compounds

• Some of these molecules are themselves cytoplasmic tyrosine kinases such as the Src kinases, TEC, and CHK [8].
• This NF-AT response was completely inhibited by the addition of cyclosporin A or FK506, but markedly enhanced by the additional expression of Tec protein tyrosine kinase [9].

Analytical, diagnostic and therapeutic context of TEC

• Molecular cloning and analysis of the human Tec protein-tyrosine kinase [10].
• Primary treatment for these SVG was performed in the following manner; PTCA 29, intragraft urokinase 12, TEC atherectomy 39 [2].

References