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Gene Review

TEC  -  tec protein tyrosine kinase

Homo sapiens

Synonyms: PSCTK4, Tyrosine-protein kinase Tec
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Disease relevance of TEC


High impact information on TEC


Biological context of TEC

  • In addition, downregulation of Akt activation in negative dominant Akt TEC enhanced TSP-1 expression and release [5].

Anatomical context of TEC

  • Recent data also show that TEC kinases contribute to T-cell-receptor-driven actin reorganization and cell polarization, which are required for productive T-cell activation [6].
  • Functional studies have implicated TEC kinases as important mediators of pathways that control the differentiation of CD4(+) T helper cells [6].
  • However, newborns and adults did not differ with regard to the percentage of cells reacting with the Leulla, Leullc and TEC NK-1, monoclonal antibodies directed against the IgG Fc receptor of killer cells [7].
  • umor-derived endothelial cells (TEC) display increased survival and angiogenic properties in respect to normal endothelial cells [5].

Associations of TEC with chemical compounds


Analytical, diagnostic and therapeutic context of TEC


  1. Dose-dense adjuvant chemotherapy in node-positive breast cancer: docetaxel followed by epirubicin/cyclophosphamide (T/EC), or the reverse sequence (EC/T), every 2 weeks, versus docetaxel, epirubicin and cyclophosphamide (TEC) every 3 weeks. AERO B03 randomized phase II study. Piedbois, P., Serin, D., Priou, F., Laplaige, P., Greget, S., Angellier, E., Teissier, E., Berdah, J.F., Fabbro, M., Valenza, B., Herait, P., Jehl, V., Buyse, M. Ann. Oncol. (2007) [Pubmed]
  2. PTCA, thrombolysis or atherectomy: rational treatment of recently occluded saphenous vein grafts. Mehta, S., Margolis, J.R., Moore, L., Pena, R. Indian heart journal. (1995) [Pubmed]
  3. The role of Tec protein-tyrosine kinase in T cell signaling. Yang, W.C., Ghiotto, M., Barbarat, B., Olive, D. J. Biol. Chem. (1999) [Pubmed]
  4. SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. Ohya, K., Kajigaya, S., Yamashita, Y., Miyazato, A., Hatake, K., Miura, Y., Ikeda, U., Shimada, K., Ozawa, K., Mano, H. J. Biol. Chem. (1997) [Pubmed]
  5. The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol 3-kinase/Akt pathway. Bussolati, B., Assenzio, B., Deregibus, M.C., Camussi, G. J. Mol. Med. (2006) [Pubmed]
  6. TEC-family kinases: regulators of T-helper-cell differentiation. Schwartzberg, P.L., Finkelstein, L.D., Readinger, J.A. Nat. Rev. Immunol. (2005) [Pubmed]
  7. Natural cytotoxicity in the neonate: high levels of lymphokine activated killer (LAK) activity. Montagna, D., Maccario, R., Ugazio, A.G., Mingrat, G., Burgio, G.R. Clin. Exp. Immunol. (1988) [Pubmed]
  8. Regulation of megakaryocytopoiesis and platelet production by tyrosine kinases and tyrosine phosphatases. Avraham, H., Price, D.J. Methods (1999) [Pubmed]
  9. SOCS-1 can suppress CD3zeta- and Syk-mediated NF-AT activation in a non-lymphoid cell line. Matsuda, T., Yamamoto, T., Kishi, H., Yoshimura, A., Muraguchi, A. FEBS Lett. (2000) [Pubmed]
  10. Molecular cloning and analysis of the human Tec protein-tyrosine kinase. Sato, K., Mano, H., Ariyama, T., Inazawa, J., Yazaki, Y., Hirai, H. Leukemia (1994) [Pubmed]
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