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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.

Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition of LPS- induced TNF-alpha production in mice and exhibited good efficacy in the rat collagen induced arthritis model.[1]


  1. Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase. Tamayo, N., Liao, L., Goldberg, M., Powers, D., Tudor, Y.Y., Yu, V., Wong, L.M., Henkle, B., Middleton, S., Syed, R., Harvey, T., Jang, G., Hungate, R., Dominguez, C. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
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