Gene Review:
Mapk14 - mitogen-activated protein kinase 14
Mus musculus
Synonyms:
CRK1, CSBP2, Crk1, Csbp1, Csbp2, ...
- p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. Warny, M., Keates, A.C., Keates, S., Castagliuolo, I., Zacks, J.K., Aboudola, S., Qamar, A., Pothoulakis, C., LaMont, J.T., Kelly, C.P. J. Clin. Invest. (2000)
- Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. Braz, J.C., Bueno, O.F., Liang, Q., Wilkins, B.J., Dai, Y.S., Parsons, S., Braunwart, J., Glascock, B.J., Klevitsky, R., Kimball, T.F., Hewett, T.E., Molkentin, J.D. J. Clin. Invest. (2003)
- Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. Park, K.M., Chen, A., Bonventre, J.V. J. Biol. Chem. (2001)
- Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes. Lim, H.W., New, L., Han, J., Molkentin, J.D. J. Biol. Chem. (2001)
- Biphasic activation of p38MAPK suggests that apoptosis is a downstream event in pemphigus acantholysis. Lee, H.E., Berkowitz, P., Jolly, P.S., Diaz, L.A., Chua, M.P., Rubenstein, D.S. J. Biol. Chem. (2009)
- Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's disease. Otth, C., Mendoza-Naranjo, A., Mujica, L., Zambrano, A., Concha, I.I., Maccioni, R.B. Neuroreport (2003)
- Attenuation of fasting-induced phosphorylation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus in response to refeeding. Ueyama, E., Morikawa, Y., Yasuda, T., Senba, E. Neurosci. Lett. (2004)
- PRAK Is Essential for ras-Induced Senescence and Tumor Suppression. Sun, P., Yoshizuka, N., New, L., Moser, B.A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., Dong, M.Q., Frangou, C.G., Yates, J.R., Wright, P.E., Han, J. Cell (2007)
- p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Zohn, I.E., Li, Y., Skolnik, E.Y., Anderson, K.V., Han, J., Niswander, L. Cell (2006)
- Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Bulavin, D.V., Phillips, C., Nannenga, B., Timofeev, O., Donehower, L.A., Anderson, C.W., Appella, E., Fornace, A.J. Nat. Genet. (2004)
- Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Kim, M.J., Park, B.J., Kang, Y.S., Kim, H.J., Park, J.H., Kang, J.W., Lee, S.W., Han, J.M., Lee, H.W., Kim, S. Nat. Genet. (2003)
- Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus. Westermann, D., Rutschow, S., Van Linthout, S., Linderer, A., Bücker-Gärtner, C., Sobirey, M., Riad, A., Pauschinger, M., Schultheiss, H.P., Tschöpe, C. Diabetologia (2006)
- Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome. Koshikawa, M., Mukoyama, M., Mori, K., Suganami, T., Sawai, K., Yoshioka, T., Nagae, T., Yokoi, H., Kawachi, H., Shimizu, F., Sugawara, A., Nakao, K. J. Am. Soc. Nephrol. (2005)
- Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-kappaB, elicits caspase activity, and enhances cytotoxicity. Lüschen, S., Scherer, G., Ussat, S., Ungefroren, H., Adam-Klages, S. Exp. Cell Res. (2004)
- Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy. Dash, R., Schmidt, A.G., Pathak, A., Gerst, M.J., Biniakiewicz, D., Kadambi, V.J., Hoit, B.D., Abraham, W.T., Kranias, E.G. Cardiovasc. Res. (2003)
- ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., Ichijo, H. Nat. Immunol. (2005)
- E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription. Lluís, F., Ballestar, E., Suelves, M., Esteller, M., Muñoz-Cánoves, P. EMBO J. (2005)
- Akt2, a novel functional link between p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in myogenesis. Gonzalez, I., Tripathi, G., Carter, E.J., Cobb, L.J., Salih, D.A., Lovett, F.A., Holding, C., Pell, J.M. Mol. Cell. Biol. (2004)
- The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase. Lee, T.H., Huang, Q., Oikemus, S., Shank, J., Ventura, J.J., Cusson, N., Vaillancourt, R.R., Su, B., Davis, R.J., Kelliher, M.A. Mol. Cell. Biol. (2003)
- Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase. Jiang, A., Craxton, A., Kurosaki, T., Clark, E.A. J. Exp. Med. (1998)
- Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. Lu, H.T., Yang, D.D., Wysk, M., Gatti, E., Mellman, I., Davis, R.J., Flavell, R.A. EMBO J. (1999)
- Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Wysk, M., Yang, D.D., Lu, H.T., Flavell, R.A., Davis, R.J. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development. Hsu, S.C., Wu, C.C., Han, J., Lai, M.Z. Blood (2003)
- Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. Brouard, S., Otterbein, L.E., Anrather, J., Tobiasch, E., Bach, F.H., Choi, A.M., Soares, M.P. J. Exp. Med. (2000)
- The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. Thomson, S., Clayton, A.L., Hazzalin, C.A., Rose, S., Barratt, M.J., Mahadevan, L.C. EMBO J. (1999)
- The cJun N-terminal kinase (JNK) signaling pathway mediates induction of urokinase-type plasminogen activator (uPA) by the alkylating agent MNNG. Parra, M., Lluís, F., Miralles, F., Caelles, C., Muñoz-Cánoves, P. Blood (2000)
- Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element-Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells. Keum, Y.S., Yu, S., Chang, P.P., Yuan, X., Kim, J.H., Xu, C., Han, J., Agarwal, A., Kong, A.N. Cancer Res. (2006)
- The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38. Zhao, Q., Shepherd, E.G., Manson, M.E., Nelin, L.D., Sorokin, A., Liu, Y. J. Biol. Chem. (2005)
- Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway. Ma, L., Wang, H.Y. J. Biol. Chem. (2007)
- Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells. Makeeva, N., Roomans, G.M., Myers, J.W., Welsh, N. Endocrinology (2008)
- SB203580, a specific inhibitor of p38-MAPK pathway, is a new reversal agent of P-glycoprotein-mediated multidrug resistance. Barancík, M., Bohácová, V., Kvackajová, J., Hudecová, S., Krizanová, O., Breier, A. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2001)
- Distinct cellular functions of MK2. Kotlyarov, A., Yannoni, Y., Fritz, S., Laass, K., Telliez, J.B., Pitman, D., Lin, L.L., Gaestel, M. Mol. Cell. Biol. (2002)
- Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. She, Q.B., Bode, A.M., Ma, W.Y., Chen, N.Y., Dong, Z. Cancer Res. (2001)
- The p38 MAPK pathway is involved in the IL-2 induction of TNF-beta gene via the EBS element. Xu, W., Yan, M., Lu, L., Sun, L., Theze, J., Zheng, Z., Liu, X. Biochem. Biophys. Res. Commun. (2001)
- MEKK1 signaling through p38 leads to transcriptional inactivation of E47 and repression of skeletal myogenesis. Page, J.L., Wang, X., Sordillo, L.M., Johnson, S.E. J. Biol. Chem. (2004)
- The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. Salvador, J.M., Mittelstadt, P.R., Belova, G.I., Fornace, A.J., Ashwell, J.D. Nat. Immunol. (2005)
- p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Briata, P., Forcales, S.V., Ponassi, M., Corte, G., Chen, C.Y., Karin, M., Puri, P.L., Gherzi, R. Mol. Cell (2005)
- Crkl is constitutively tyrosine phosphorylated in platelets from chronic myelogenous leukemia patients and inducibly phosphorylated in normal platelets stimulated by thrombopoietin. Oda, A., Miyakawa, Y., Druker, B.J., Ishida, A., Ozaki, K., Ohashi, H., Wakui, M., Handa, M., Watanabe, K., Okamoto, S., Ikeda, Y. Blood (1996)
- Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase. Xu, G.L., Yao, L., Rao, S.Y., Gong, Z.N., Zhang, S.Q., Yu, S.Q. Journal of ethnopharmacology. (2005)
- Mechanism of p38 MAP kinase activation in vivo. Brancho, D., Tanaka, N., Jaeschke, A., Ventura, J.J., Kelkar, N., Tanaka, Y., Kyuuma, M., Takeshita, T., Flavell, R.A., Davis, R.J. Genes Dev. (2003)
- Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Bulavin, D.V., Kovalsky, O., Hollander, M.C., Fornace, A.J. Mol. Cell. Biol. (2003)
- p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Hui, L., Bakiri, L., Mairhorfer, A., Schweifer, N., Haslinger, C., Kenner, L., Komnenovic, V., Scheuch, H., Beug, H., Wagner, E.F. Nat. Genet. (2007)
- Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells. Caverzasio, J., Manen, D. Endocrinology (2007)
- The role of RIP2 in p38 MAPK activation in the stressed heart. Jacquet, S., Nishino, Y., Kumphune, S., Sicard, P., Clark, J.E., Kobayashi, K.S., Flavell, R.A., Eickhoff, J., Cotten, M., Marber, M.S. J. Biol. Chem. (2008)
- Identification of MAP kinase domains by redirecting stress signals into growth factor responses. Brunet, A., Pouysségur, J. Science (1996)
- c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Stepniak, E., Ricci, R., Eferl, R., Sumara, G., Sumara, I., Rath, M., Hui, L., Wagner, E.F. Genes Dev. (2006)
- Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. Zhang, R., Murakami, S., Coustry, F., Wang, Y., de Crombrugghe, B. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes. Meissner, J.D., Chang, K.C., Kubis, H.P., Nebreda, A.R., Gros, G., Scheibe, R.J. J. Biol. Chem. (2007)
- RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. Mikkelsen, S.S., Jensen, S.B., Chiliveru, S., Melchjorsen, J., Julkunen, I., Gaestel, M., Arthur, J.S., Flavell, R.A., Ghosh, S., Paludan, S.R. J. Biol. Chem. (2009)
- Hepatic ischemic preconditioning in mice is associated with activation of NF-kappaB, p38 kinase, and cell cycle entry. Teoh, N., Dela Pena, A., Farrell, G. Hepatology (2002)
- P38 and activating transcription factor-2 involvement in osteoblast osmotic response to elevated extracellular glucose. Zayzafoon, M., Botolin, S., McCabe, L.R. J. Biol. Chem. (2002)
- MAPK-activated Protein Kinase-2 (MK2)-mediated Formation and Phosphorylation-regulated Dissociation of the Signal Complex Consisting of p38, MK2, Akt, and Hsp27. Zheng, C., Lin, Z., Zhao, Z.J., Yang, Y., Niu, H., Shen, X. J. Biol. Chem. (2006)
- Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK. Molnár, A., Theodoras, A.M., Zon, L.I., Kyriakis, J.M. J. Biol. Chem. (1997)
- p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. Iwata, Y., Wada, T., Furuichi, K., Sakai, N., Matsushima, K., Yokoyama, H., Kobayashi, K. J. Am. Soc. Nephrol. (2003)