Chemical Compound Review:
pyridazine pyridazine
Synonyms:
van Niel,
Wilson,
Adkins,
Atack,
Castro,
Clarke,
Fletcher,
Gerhard,
Mackey,
Malpas,
Maubach,
Newman,
O'Connor,
Pillai,
Simpson,
Thomas,
MacLeod,
O'Donnell,
Dalvie,
Kalgutkar,
Obach,
Tamayo,
Liao,
Goldberg,
Powers,
Tudor,
Yu,
Wong,
Henkle,
Middleton,
Syed,
Harvey,
Jang,
Hungate,
Dominguez,
Lattmann,
Ayuko,
Kinchinaton,
Langley,
Singh,
Karimi,
Tisdale,
Deeb,
El-Mariah,
Hosny,
Bongartz,
Stokbroekx,
Van der Aa,
Luyckx,
Willems,
Ceusters,
Meerpoel,
Smets,
Jansen,
Wouters,
Bowden,
Valletta,
Herb,
Tominovich,
Tuman,
Watterson,
Mirzoeva,
Guo,
Whyte,
Bourguignon,
Hibert,
Haiech,
Van Eldik,
- Hemodynamic effects of oxdralazine and hydralazine in hypertension. Moskowitz, R.M., Cohn, J.N. Clin. Pharmacol. Ther. (1980)
- The in vivo metabolism of 3-oxo-5-benzylidene-6-methyl-(4H)-2-(benzoylmethyl)pyridazine in rats. Oruç, E.E., Unsal, O., Balkan, A., Ozkanli, F., Gören, M.Z., Terzioğlu, B., Rollas, S. European journal of drug metabolism and pharmacokinetics. (2006)
- Effects of 3-[N-(2-chlorobenzyl)amino]-6-(1H-imidazol-1-yl) pyridazine dihydrochloride on various aromatase enzyme systems and experimental breast cancer. Bandoh, K., Ishizuka, Y., Sato, M. Arzneimittel-Forschung. (1995)
- A new pyridazine series of GABAA alpha5 ligands. van Niel, M.B., Wilson, K., Adkins, C.H., Atack, J.R., Castro, J.L., Clarke, D.E., Fletcher, S., Gerhard, U., Mackey, M.M., Malpas, S., Maubach, K., Newman, R., O'Connor, D., Pillai, G.V., Simpson, P.B., Thomas, S.R., MacLeod, A.M. J. Med. Chem. (2005)
- Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors. Contreras, J.M., Parrot, I., Sippl, W., Rival, Y.M., Wermuth, C.G. J. Med. Chem. (2001)
- Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors. Dal Piaz, V., Giovannoni, M.P., Castellana, C., Palacios, J.M., Beleta, J., Doménech, T., Segarra, V. J. Med. Chem. (1997)
- Heterogeneity of gamma-aminobutyric acid/benzodiazepine/beta-carboline receptor complex in rat spinal cord. Santi, M.R., Cox, D.H., Guidotti, A. J. Neurochem. (1988)
- Tetracyclic pyridazines as potential psychopharmacological agents. Ross, B.S., Wiley, R.A. J. Med. Chem. (1985)
- Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy. Hallot, A., Brodin, R., Merlier, J., Brochard, J., Chambon, J.P., Biziere, K. J. Med. Chem. (1986)
- A novel series of non-nucleoside inhibitors of inosine 5'-monophosphate dehydrogenase with immunosuppressive activity. Franklin, T.J., Morris, W.P., Jacobs, V.N., Culbert, E.J., Heys, C.A., Ward, W.H., Cook, P.N., Jung, F., Plé, P. Biochem. Pharmacol. (1999)
- Neuropharmacology of a new potential anxiolytic compound, F 2692, 1-(3'-trifluoromethyl phenyl) 1,4-dihydro 3-amino 4-oxo 6-methyl pyridazine. 1. Acute and in vitro effects. Assié, M.B., Chopin, P., Stenger, A., Palmier, C., Briley, M. Psychopharmacology (Berl.) (1993)
- Synthesis and evaluation of 5-arylated 2(5H)-furanones and 2-arylated pyridazin-3(2H)-ones as anti-cancer agents. Lattmann, E., Ayuko, W.O., Kinchinaton, D., Langley, C.A., Singh, H., Karimi, L., Tisdale, M.J. J. Pharm. Pharmacol. (2003)
- Differential induction of rat hepatic microsomal epoxide hydrolase and rGSTA2 by diazines: the role of cytochrome P450 2E1-mediated metabolic activation. Cho, M.K., Kim, S.G. Chem. Biol. Interact. (1998)
- Cytostatic activity of pyridazine derivatives. I. In vitro studies on 1-methoxyphenylpyridazine-6-ones. Hładoń, B., Bałoniak, S., Szafarek, P., Zyczyńska-Bałoniak, I. Arch. Immunol. Ther. Exp. (Warsz.) (1980)
- Novel arylaminopyridazine-GABA receptor antagonists examined electrophysiologically in Ascaris suum. Martin, R.J., Sitamze, J.M., Duittoz, A.H., Wermuth, C.G. Eur. J. Pharmacol. (1995)
- Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen. O'Donnell, J.P., Dalvie, D.K., Kalgutkar, A.S., Obach, R.S. Drug Metab. Dispos. (2003)
- A spectroscopic study of the molecular interactions of harmane with pyrimidine and other diazines. Muñoz, M.A., Guardado, P., Galán, M., Carmona, C., Balón, M. Biophys. Chem. (2000)
- Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives. Bongartz, J.P., Stokbroekx, R., Van der Aa, M., Luyckx, M., Willems, M., Ceusters, M., Meerpoel, L., Smets, G., Jansen, T., Wouters, W., Bowden, C., Valletta, L., Herb, M., Tominovich, R., Tuman, R. Bioorg. Med. Chem. Lett. (2002)
- Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II. Watterson, D.M., Mirzoeva, S., Guo, L., Whyte, A., Bourguignon, J.J., Hibert, M., Haiech, J., Van Eldik, L.J. Neurochem. Int. (2001)
- Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase. Tamayo, N., Liao, L., Goldberg, M., Powers, D., Tudor, Y.Y., Yu, V., Wong, L.M., Henkle, B., Middleton, S., Syed, R., Harvey, T., Jang, G., Hungate, R., Dominguez, C. Bioorg. Med. Chem. Lett. (2005)
- Pyridazine derivatives and related compounds. Part 13: Synthesis and antimicrobial activity of some pyridazino[3',4':3,4]pyrazolo[5,1-c]-1,2,4-triazines. Deeb, A., El-Mariah, F., Hosny, M. Bioorg. Med. Chem. Lett. (2004)
- Synthesis and analgesic effects of 3-substituted 4,6-diarylpyridazine derivatives of the arylpiperazine class. Rohet, F., Rubat, C., Coudert, P., Couquelet, J. Bioorg. Med. Chem. (1997)
- Pulsed-field ionization electron spectroscopy and ab initio calculations of copper-diazine complexes. Wang, X., Lee, J.S., Yang, D.S. The Journal of chemical physics. (2006)
- Bioassay of the vasodepressor and cardiostimulatory effects of hydralazine and pyridazine derivative (DL-150) in hypertensive patients. Pasotti, C., Nicrosini, F., Marchetti, M., Manzini, A., Nicolis, F.B. Il Farmaco; edizione pratica. (1976)