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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A.

Two bromopyrrole marine alkaloids were isolated from the Mexican sponge, Agelas sp.: hymenidin (1) and agelastatin A (2). The structures were elucidated by analysis of their spectroscopic data and found to correspond to those in the literature. The absolute configuration of agelastatin A (2) was elucidated by single-crystal X-ray diffraction methods. Agelastatin A (2) exhibited strong activity against a panel of human cancer cell lines as well as human umbilical vein endothelial cells.[1]

References

  1. Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A. Pettit, G.R., Ducki, S., Herald, D.L., Doubek, D.L., Schmidt, J.M., Chapuis, J.C. Oncol. Res. (2005) [Pubmed]
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