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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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 Nemere,  
 

The 1,25D3-MARRS protein: contribution to steroid stimulated calcium uptake in chicks and rats.

There are currently two main candidates for the membrane receptor for 1,25(OH)2D3: the 1,25D3-MARRS protein/ ERp57; and the classical VDR. The 1,25D3-MARRS protein is essential for hormone-stimulated phosphate and calcium uptake in chick intestinal cells, whereas the VDR is not. The 1,25D3-MARRS protein also shows a high degree of correlation with growth periods in which bone is rapidly formed, whereas the VDR does not. However, in rat enterocytes, both the 1,25D3-MARRS protein and the VDR play a role in the rapid, steroid-mediated uptake of phosphate or calcium. Therefore, the theory that alternate binding sites on the VDR for various analogs account for all membrane-initiated phenomena, is incorrect.[1]

References

  1. The 1,25D3-MARRS protein: contribution to steroid stimulated calcium uptake in chicks and rats. Nemere, I. Steroids (2005) [Pubmed]
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