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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A hybrid quantum dot-antibody fragment fluorescence resonance energy transfer-based TNT sensor.

We demonstrate the use of luminescent QDs conjugated to antibody fragments to develop solution-phase nanoscale sensing assemblies, based on fluorescence resonance energy transfer (FRET) for the specific detection of the explosive 2,4,6-trinitrotoluene (TNT) in aqueous environments. The hybrid sensor consists of anti-TNT specific antibody fragments attached to a hydrophilic QD via metal-affinity coordination. A dye-labeled TNT analogue prebound in the antibody binding site quenches the QD photoluminescence via proximity-induced FRET. Analysis of the data collected at increasing dye-labeled analogue to QD ratios provided an insight into understanding how the antibody fragments self-assemble on the QD. Addition of soluble TNT displaces the dye-labeled analogue, eliminating FRET and resulting in a concentration-dependent recovery of QD photoluminescence. Sensor performance and specificity were evaluated.[1]


  1. A hybrid quantum dot-antibody fragment fluorescence resonance energy transfer-based TNT sensor. Goldman, E.R., Medintz, I.L., Whitley, J.L., Hayhurst, A., Clapp, A.R., Uyeda, H.T., Deschamps, J.R., Lassman, M.E., Mattoussi, H. J. Am. Chem. Soc. (2005) [Pubmed]
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