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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

SDHC mutations in hereditary paraganglioma/pheochromocytoma.

Mutations in genes coding for three of the four components of mitochondrial complex II can cause paragangliomas (PGLs)/pheochromocytomas. The three genes include SDHB, -C, and -D. SDHC and SDHD anchor the catalytic subunits SDHA and -B of mitochondrial complex II in the inner mitochondrial membrane. SDHD is maternally imprinted but SDHB and -C are not. While SDHD and -- to a lesser degree -- SDHB mutations have been found in many cases of hereditary PGL, SDHC mutations are rare. This article reviews the SDHC mutations described to date and discusses possible mechanisms of tumorigenesis.[1]


  1. SDHC mutations in hereditary paraganglioma/pheochromocytoma. Müller, U., Troidl, C., Niemann, S. Fam. Cancer (2005) [Pubmed]
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