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Gene Review

SDHC  -  succinate dehydrogenase complex, subunit C...

Homo sapiens

Synonyms: CYB560, CYBL, Integral membrane protein CII-3, PGL3, QPS1, ...
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Disease relevance of SDHC


High impact information on SDHC

  • Mutations in SDHC cause autosomal dominant paraganglioma, type 3 [5].
  • Hereditary paraganglioma syndrome has recently been shown to be caused by germline heterozygous mutations in three (SDHB, SDHC, and SDHD) of the four genes that encode mitochondrial succinate dehydrogenase [6].
  • These data show that SDHC mutations cause increased O2(.-) production, metabolic oxidative stress, and genomic instability and that mutations in genes coding for mitochondrial electron transport chain proteins can contribute to phenotypic changes associated with cancer cells [7].
  • Expression of wild-type (WT) human SDHC in B9 cells caused prooxidant production, glucose consumption, sensitivity to glucose deprivation-induced cytotoxicity, and aneuploidy to revert to the WT phenotype [7].
  • The SDHC E69 cells overproduced superoxide anion (O(2)(-)) from mitochondria, had elevated cytoplasmic carbonyl proteins and 8-OH-deoxyguanine in their DNA as well as significantly higher mutation frequencies than wild type [8].

Biological context of SDHC


Anatomical context of SDHC

  • Characterization of the human SDHC gene encoding of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria [9].
  • Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23 [10].
  • In addition, some cells that escaped from apoptosis underwent transformation, as evidenced by the fact that SDHC E69 cells caused benign tumors when injected under the epithelium of nude mice [8].
  • In this study, we examined the level of expression of mRNAs encoding SDHB, SDHC, and SDHD in pheochromocytoma, pheochromocytoma subgroups, and normal adrenal gland, and compared the expression of these genes to the level of expression of related genes in the same tissues [13].

Associations of SDHC with chemical compounds

  • Here we report frequent transfer of two respiratory genes, sdh3 and sdh4 (encoding subunits 3 and 4 of succinate dehydrogenase), and we also show that these genes are present and expressed in the mitochondria of diverse angiosperms [14].
  • The luciferase activity of the integrin beta3 plasmid PGL3 - 1486 approximately - 900 increased by 84.72% in response to angiotensin II [15].

Other interactions of SDHC

  • Under the assumption of a single locus, the critical region for FAT1 has been reduced to a 3.3 cM interval between the RXRG and SDHC loci [16].
  • A mev-1 mutation in the cytochrome b large subunit (SDHC) of complex II results in superoxide anion (O2-) overproduction and therefore leads to apoptosis and precocious aging in the nematode Caenorhabditis elegans [17].


  1. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Astuti, D., Latif, F., Dallol, A., Dahia, P.L., Douglas, F., George, E., Sköldberg, F., Husebye, E.S., Eng, C., Maher, E.R. Am. J. Hum. Genet. (2001) [Pubmed]
  2. Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. Bayley, J.P., van Minderhout, I., Weiss, M.M., Jansen, J.C., Oomen, P.H., Menko, F.H., Pasini, B., Ferrando, B., Wong, N., Alpert, L.C., Williams, R., Blair, E., Devilee, P., Taschner, P.E. BMC Med. Genet. (2006) [Pubmed]
  3. No Association of an SDHC Gene Polymorphism with Gastric Cancer. Goto, Y., Ando, T., Naito, M., Goto, H., Hamajima, N. Asian Pac. J. Cancer Prev. (2006) [Pubmed]
  4. Nuclear localization signal peptides enhance cationic liposome-mediated gene therapy. Aronsohn, A.I., Hughes, J.A. Journal of drug targeting. (1998) [Pubmed]
  5. Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Niemann, S., Müller, U. Nat. Genet. (2000) [Pubmed]
  6. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. Vanharanta, S., Buchta, M., McWhinney, S.R., Virta, S.K., Peçzkowska, M., Morrison, C.D., Lehtonen, R., Januszewicz, A., Järvinen, H., Juhola, M., Mecklin, J.P., Pukkala, E., Herva, R., Kiuru, M., Nupponen, N.N., Aaltonen, L.A., Neumann, H.P., Eng, C. Am. J. Hum. Genet. (2004) [Pubmed]
  7. Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Slane, B.G., Aykin-Burns, N., Smith, B.J., Kalen, A.L., Goswami, P.C., Domann, F.E., Spitz, D.R. Cancer Res. (2006) [Pubmed]
  8. A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. Ishii, T., Yasuda, K., Akatsuka, A., Hino, O., Hartman, P.S., Ishii, N. Cancer Res. (2005) [Pubmed]
  9. Characterization of the human SDHC gene encoding of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria. Elbehti-Green, A., Au, H.C., Mascarello, J.T., Ream-Robinson, D., Scheffler, I.E. Gene (1998) [Pubmed]
  10. Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23. Hirawake, H., Taniwaki, M., Tamura, A., Kojima, S., Kita, K. Cytogenet. Cell Genet. (1997) [Pubmed]
  11. The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency. Bayley, J.P., Devilee, P., Taschner, P.E. BMC Med. Genet. (2005) [Pubmed]
  12. SDHC mutations in hereditary paraganglioma/pheochromocytoma. Müller, U., Troidl, C., Niemann, S. Fam. Cancer (2005) [Pubmed]
  13. Expression of mRNAs for Succinate Dehydrogenase Subunits and Related Genes in Pheochromocytoma. Isobe, K., Nissato, S., Tatsuno, I., Yashiro, T., Takekoshi, K., Kawakami, Y. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  14. Multiple losses and transfers to the nucleus of two mitochondrial succinate dehydrogenase genes during angiosperm evolution. Adams, K.L., Rosenblueth, M., Qiu, Y.L., Palmer, J.D. Genetics (2001) [Pubmed]
  15. Angiotensin II stimulates endothelial integrin beta3 expression via nuclear factor-kappaB activation. Li, S., Wang, X., Qiu, J., Si, Q., Wang, H., Guo, H., Sun, R., Wu, Q. Experimental aging research. (2006) [Pubmed]
  16. Refined localization of the FAT1 quantitative trait locus on pig chromosome 4 by marker-assisted backcrossing. Berg, F., Stern, S., Andersson, K., Andersson, L., Moller, M. BMC Genet. (2006) [Pubmed]
  17. The role of the electron transport gene SDHC on lifespan and cancer. Ishii, N., Ishii, T., Hartman, P.S. Exp. Gerontol. (2006) [Pubmed]
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