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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response.

We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis ( MS) susceptibility and in the IFNbeta treatment response in a group of 147 patients and 210 controls undergoing interferon therapy during the last 2 years. Only the 18417 and the 11876 SNPs showed an association with disease susceptibility (p=0.001 and 0.035, respectively) although no differential genotype distribution were observed between interferon responders and non-responder MS patients. No alteration of the expression level of IFNAR-1 was observed with respect to the -408 genotypes or to interferon treatment response. These data suggest a role for the IFNAR pathway in susceptibility to MS.[1]

References

  1. IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. Leyva, L., Fernández, O., Fedetz, M., Blanco, E., Fernández, V.E., Oliver, B., León, A., Pinto-Medel, M.J., Mayorga, C., Guerrero, M., Luque, G., Alcina, A., Matesanz, F. J. Neuroimmunol. (2005) [Pubmed]
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