Gene Review:
IFNAR2 - interferon (alpha, beta and omega) receptor 2
Homo sapiens
Synonyms:
IFN-R, IFN-R-2, IFN-alpha binding protein, IFN-alpha-REC, IFN-alpha/beta receptor 2, ...
- IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. Leyva, L., Fernández, O., Fedetz, M., Blanco, E., Fernández, V.E., Oliver, B., León, A., Pinto-Medel, M.J., Mayorga, C., Guerrero, M., Luque, G., Alcina, A., Matesanz, F. J. Neuroimmunol. (2005)
- The relative endogenous expression levels of the IFNAR2 isoforms influence the cytostatic and pro-apoptotic effect of IFNalpha on pleomorphic sarcoma cells. Gazziola, C., Cordani, N., Carta, S., De Lorenzo, E., Colombatti, A., Perris, R. Int. J. Oncol. (2005)
- Type I interferon receptor and response to interferon therapy in chronic hepatitis C patients: a prospective study. Fujiwara, D., Hino, K., Yamaguchi, Y., Kubo, Y., Yamashita, S., Uchida, K., Konishi, T., Nakamura, H., Korenaga, M., Okuda, M., Okita, K. J. Viral Hepat. (2004)
- Initial expression of interferon alpha receptor 2 (IFNAR2) on CD34-positive cells and its down-regulation correlate with clinical response to interferon therapy in chronic myelogenous leukemia. Ito, K., Tanaka, H., Ito, T., Sultana, T.A., Kyo, T., Imanaka, F., Ohmoto, Y., Kimura, A. Eur. J. Haematol. (2004)
- SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. Kumar, K.G., Tang, W., Ravindranath, A.K., Clark, W.A., Croze, E., Fuchs, S.Y. EMBO J. (2003)
- Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. Lutfalla, G., Holland, S.J., Cinato, E., Monneron, D., Reboul, J., Rogers, N.C., Smith, J.M., Stark, G.R., Gardiner, K., Mogensen, K.E. EMBO J. (1995)
- Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. Frodsham, A.J., Zhang, L., Dumpis, U., Taib, N.A., Best, S., Durham, A., Hennig, B.J., Hellier, S., Knapp, S., Wright, M., Chiaramonte, M., Bell, J.I., Graves, M., Whittle, H.C., Thomas, H.C., Thursz, M.R., Hill, A.V. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking. Roisman, L.C., Piehler, J., Trosset, J.Y., Scheraga, H.A., Schreiber, G. Proc. Natl. Acad. Sci. U.S.A. (2001)
- IFNalpha/beta promotes cell survival by activating NF-kappa B. Yang, C.H., Murti, A., Pfeffer, S.R., Basu, L., Kim, J.G., Pfeffer, L.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Association of mumps virus V protein with RACK1 results in dissociation of STAT-1 from the alpha interferon receptor complex. Kubota, T., Yokosawa, N., Yokota, S., Fujii, N. J. Virol. (2002)
- Is an "a la carte" combination interferon alfa-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C? The ALGOVIRC Project Group. Poynard, T., McHutchison, J., Goodman, Z., Ling, M.H., Albrecht, J. Hepatology (2000)
- Molecular cloning of ovine and bovine type I interferon receptor subunits from uteri, and endometrial expression of messenger ribonucleic acid for ovine receptors during the estrous cycle and pregnancy. Han, C.S., Mathialagan, N., Klemann, S.W., Roberts, R.M. Endocrinology (1997)
- The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a threshold of interferon alpha-induced Stat2 tyrosine phosphorylation that allows normal formation of interferon-stimulated gene factor 3. Nadeau, O.W., Domanski, P., Usacheva, A., Uddin, S., Platanias, L.C., Pitha, P., Raz, R., Levy, D., Majchrzak, B., Fish, E., Colamonici, O.R. J. Biol. Chem. (1999)
- Interferon-dependent activation of the serine kinase PI 3'-kinase requires engagement of the IRS pathway but not the Stat pathway. Uddin, S., Majchrzak, B., Wang, P.C., Modi, S., Khan, M.K., Fish, E.N., Platanias, L.C. Biochem. Biophys. Res. Commun. (2000)
- Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness. Raz, R., Cheung, K., Ling, L., Levy, D.E. Somat. Cell Mol. Genet. (1995)
- Expression of interferon receptor genes (IFNAR1 and IFNAR2 mRNA) in the liver may predict outcome after interferon therapy in patients with chronic genotype 2a or 2b hepatitis C virus infection. Morita, K., Tanaka, K., Saito, S., Kitamura, T., Kondo, M., Sakaguchi, T., Morimoto, M., Sekihara, H. J. Clin. Gastroenterol. (1998)
- The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells. Pogue, S.L., Preston, B.T., Stalder, J., Bebbington, C.R., Cardarelli, P.M. J. Interferon Cytokine Res. (2004)
- Temporal expression of type I interferon receptor in the peri-implantation ovine extra-embryonic membranes: demonstration that human IFNalpha can bind to this receptor. Imakawa, K., Tamura, K., Lee, R.S., Ji, Y., Kogo, H., Sakai, S., Christenson, R.K. Endocr. J. (2002)
- Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta. Jaitin, D.A., Roisman, L.C., Jaks, E., Gavutis, M., Piehler, J., Van der Heyden, J., Uze, G., Schreiber, G. Mol. Cell. Biol. (2006)
- Direct signal transduction via functional interferon-alphabeta receptors in CD34+ hematopoietic stem cells. Giron-Michel, J., Weill, D., Bailly, G., Legras, S., Nardeux, P.C., Azzarone, B., Tovey, M.G., Eid, P. Leukemia (2002)
- Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression. Ota, H., Nagano, H., Sakon, M., Eguchi, H., Kondo, M., Yamamoto, T., Nakamura, M., Damdinsuren, B., Wada, H., Marubashi, S., Miyamoto, A., Dono, K., Umeshita, K., Nakamori, S., Wakasa, K., Monden, M. Br. J. Cancer (2005)
- Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Colamonici, O., Yan, H., Domanski, P., Handa, R., Smalley, D., Mullersman, J., Witte, M., Krishnan, K., Krolewski, J. Mol. Cell. Biol. (1994)
- New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface. Piehler, J., Roisman, L.C., Schreiber, G. J. Biol. Chem. (2000)
- Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling. Expression of IFNAR2c truncation mutants in U5A cells. Russell-Harde, D., Wagner, T.C., Rani, M.R., Vogel, D., Colamonici, O., Ransohoff, R.M., Majchrzak, B., Fish, E., Perez, H.D., Croze, E. J. Biol. Chem. (2000)
- Stat1 is induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells. Gianni, M., Terao, M., Fortino, I., LiCalzi, M., Viggiano, V., Barbui, T., Rambaldi, A., Garattini, E. Blood (1997)
- Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2. Chuntharapai, A., Gibbs, V., Lu, J., Ow, A., Marsters, S., Ashkenazi, A., De Vos, A., Jin Kim, K. J. Immunol. (1999)
- Identification of critical residues in bovine IFNAR-1 responsible for interferon binding. Cutrone, E.C., Langer, J.A. J. Biol. Chem. (2001)
- Activation of a CrkL-stat5 signaling complex by type I interferons. Fish, E.N., Uddin, S., Korkmaz, M., Majchrzak, B., Druker, B.J., Platanias, L.C. J. Biol. Chem. (1999)
- Systematic mutational mapping of sites on human interferon-beta-1a that are important for receptor binding and functional activity. Runkel, L., deDios, C., Karpusas, M., Betzenhauser, M., Muldowney, C., Zafari, M., Benjamin, C.D., Miller, S., Hochman, P.S., Whitty, A. Biochemistry (2000)
- Interferon alpha (IFN alpha) signaling in cells expressing the variant form of the type I IFN receptor. Colamonici, O.R., Domanski, P., Krolewski, J.J., Fu, X.Y., Reich, N.C., Pfeffer, L.M., Sweet, M.E., Platanias, L.C. J. Biol. Chem. (1994)
- Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation. Russell-Harde, D., Wagner, T.C., Perez, H.D., Croze, E. Biochem. Biophys. Res. Commun. (1999)
- Blockade of TLR9 agonist-induced type I interferons promotes inflammatory cytokine IFN-gamma and IL-17 secretion by activated human PBMC. Meyers, J.A., Mangini, A.J., Nagai, T., Roff, C.F., Sehy, D., van Seventer, G.A., van Seventer, J.M. Cytokine (2006)
- Retinoic acid-induced protein ISGylation is dependent on interferon signal transduction. Dao, C.T., Luo, J.K., Zhang, D.E. Blood Cells Mol. Dis. (2006)
- A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs. Liang, K.H., Yeh, C.T. BMC. Genomics. (2013)
- Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. Uddin, S., Chamdin, A., Platanias, L.C. J. Biol. Chem. (1995)
- STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues. Velichko, S., Wagner, T.C., Turkson, J., Jove, R., Croze, E. J. Biol. Chem. (2002)
- Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation. Usacheva, A., Sandoval, R., Domanski, P., Kotenko, S.V., Nelms, K., Goldsmith, M.A., Colamonici, O.R. J. Biol. Chem. (2002)
- Characterization of a soluble ternary complex formed between human interferon-beta-1a and its receptor chains. Arduini, R.M., Strauch, K.L., Runkel, L.A., Carlson, M.M., Hronowski, X., Foley, S.F., Young, C.N., Cheng, W., Hochman, P.S., Baker, D.P. Protein Sci. (1999)
- Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2. Owczarek, C.M., Hwang, S.Y., Holland, K.A., Gulluyan, L.M., Tavaria, M., Weaver, B., Reich, N.C., Kola, I., Hertzog, P.J. J. Biol. Chem. (1997)
- Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth. van Koetsveld, P.M., Vitale, G., de Herder, W.W., Feelders, R.A., van der Wansem, K., Waaijers, M., van Eijck, C.H., Speel, E.J., Croze, E., van der Lely, A.J., Lamberts, S.W., Hofland, L.J. J. Clin. Endocrinol. Metab. (2006)
- Expression of type I interferon receptor as a predictor of clinical response to interferon-alpha therapy of gastrointestinal cancers. Ota, H., Nagano, H., Doki, Y., Sekimoto, M., Kondo, M., Wada, H., Nakamura, M., Noda, T., Damdinsuren, B., Marubashi, S., Miyamoto, A., Takeda, Y., Dono, K., Umeshita, K., Nakamori, S., Wakasa, K., Sakon, M., Monden, M. Oncol. Rep. (2006)