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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line.

Genetic and biochemical studies of mammalian DNA ligase I indicate that this multifunctional enzyme plays a key role in the completion of DNA replication and certain DNA excision repair pathways. However, the involvement of DNA ligase I in DNA double-strand break repair has not been examined. Here we have determined the effect of DNA ligase I-deficiency on the frequency of homologous recombination initiated by a site-specific DNA double-strand break. We found that expression of wild-type DNA ligase I in a human DNA ligase I mutant cell line significantly increased the frequency of homologous recombination. Notably, the ability of DNA ligase I to promote the recombinational repair of DNA double-strand breaks was dependent upon its interaction with proliferating cell nuclear antigen. Thus, our results demonstrate that DNA ligase I-deficiency reduces recombinational repair of DNA double-strand breaks.[1]

References

  1. Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line. Goetz, J.D., Motycka, T.A., Han, M., Jasin, M., Tomkinson, A.E. DNA Repair (Amst.) (2005) [Pubmed]
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