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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A newly discovered function for RNase L in regulating translation termination.

The antiviral and antiproliferative effects of interferons are mediated in part by the 2'-5' oligoadenylate-RNase L RNA decay pathway. RNase L is an endoribonuclease that requires 2'-5' oligoadenylates to cleave single-stranded RNA. In this report we present evidence demonstrating a role for RNase L in translation. We identify and characterize the human translation termination factor eRF3/GSPT1 as an interacting partner of RNase L. We show that interaction of eRF3 with RNase L leads to both increased translation readthrough efficiency at premature termination codons and increased +1 frameshift efficiency at the antizyme +1 frameshift site. On the basis of our results, we present a model describing how RNase L is involved in regulating gene expression by modulating the translation termination process.[1]


  1. A newly discovered function for RNase L in regulating translation termination. Le Roy, F., Salehzada, T., Bisbal, C., Dougherty, J.P., Peltz, S.W. Nat. Struct. Mol. Biol. (2005) [Pubmed]
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