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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hennig, L. et al.

Hennig, Bouveret, Gruissem,

MSI1-like proteins: an escort service for chromatin assembly and remodeling complexes.

MSI1-like WD40 repeat proteins are subunits of many protein complexes controlling chromatin dynamics. These proteins do not have any catalytic activity, but several recent studies using loss-of-function mutants established specific functions during development. Here, we review the current knowledge of MSI1-like proteins, including their phylogenetic history, expression patterns, biochemical interactions and mutant phenotypes. MSI1-like proteins, which are often targets or partners of tumor-suppressor proteins, are required during cell proliferation and differentiation in flies, nematodes and plants. We discuss the possibility that MSI1-like proteins could function to maintain epigenetic memory during development by targeting silencing complexes to chromatin during nucleosome assembly.[1]

References

MSI1-like proteins: an escort service for chromatin assembly and remodeling complexes. Hennig, L., Bouveret, R., Gruissem, W. Trends Cell Biol. (2005) [Pubmed]

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