Disease relevance of MSI1

• Thus, we expect the analysis of MSI1 expression to contribute to the understanding of the cellular origin and biology of human gliomas [1].
• In glioblastomas, MSI1 was expressed in GFAP-negative tumor cells forming foci that were clearly demarcated and surrounded by GFAP-positive cells [1].
• The percentage of MSI1-labeled tumor cells increased in higher-grade astrocytomas and correlated with proliferative activity, as estimated by an MIB-1 staining index [1].
• Musashi-1 (Msi-1), an RNA-binding protein associated with neural progenitor cells, has been shown by others to increase the accumulation of tau isoforms in intracellular inclusions in frontotemporal dementia and parkinsonism linked to chromosome 17 [2].
• Boron neutron capture therapy (BNCT) of malignant brain tumors has been efficiently performed since March 1977, and the first human case of malignant melanoma was also successfully treated on July 1987 in our reactor (Musashi reactor, TRIGA-II, 100 kW) [3].
• Musashi-1 expressing stromal cell and cell group numbers were significantly increased (five-fold) in both endometriotic and endometrial carcinoma tissue compared to secretory endometrium [4].

High impact information on MSI1

• MSI1-like proteins: an escort service for chromatin assembly and remodeling complexes [5].
• Here, we review the current knowledge of MSI1-like proteins, including their phylogenetic history, expression patterns, biochemical interactions and mutant phenotypes [5].
• MSI1-like proteins, which are often targets or partners of tumor-suppressor proteins, are required during cell proliferation and differentiation in flies, nematodes and plants [5].
• BM-derived cells did not distribute within the crypt as stem cells and rarely expressed Musashi-1 [6].
• These results reveal that the functions of FAS1, FAS2 and MSI1 are not restricted to meristems, but are also needed to control genome replication at multiple steps of development [7].

Chemical compound and disease context of MSI1

• Investigation of musashi-1 expressing cells in the murine model of dextran sodium sulfate-induced colitis [8].

Biological context of MSI1

• Musashi-1 and Ki-67-positive precursor cells from AD self renew, but reach senescence earlier than cells isolated from normal aged control subjects [9].

Anatomical context of MSI1

• The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells [10].
• As we had seen previously in rodents, in the normal human brain, MSI1 was expressed in cells located in the ventricular and subventricular zones, in GFAP-negative glial cells, and in GFAP-positive astrocytes [1].
• Furthermore activation of the neural ELAV proteins by phorbol esters in human SH-SY5Y cells is associated with an increase of Musashi-1 protein content in the cytoskeleton [11].
• In addition to its functions in NSCs, the role of mammalian Musashi-1 protein in epithelial stem cells, including intestinal and mammary gland stem cells, is attracting increasing interest [12].
• Musashi-1 was expressed by small cells that were mainly vimentin+ or nestin+, rarely Dcx+ or PSA-NCAM+ and negative for markers of mature neurons or astrocytes [13].

Other interactions of MSI1

• In this study we describe an efficient method for differentiating rhesus monkey ES cells to neural lineages and the subsequent isolation of an enriched population of Nestin and Musashi positive neural progenitor (NP) cells [14].

References