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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.

A series of potent and selective inhibitors of the inducible microsomal PGE2 synthase (mPGES-1) has been developed based on the indole FLAP inhibitor MK-886. Compounds 23 and 30 inhibit mPGES-1 with potencies in the low nanomolar range and with selectivities of at least 100-fold compared to their inhibition of mPGES-2, thromboxane synthase and binding affinity to FLAP. They also block the production of PGE2 in cell based assays but with a decreased potency and more limited selectivity compared to the enzyme assays.[1]

References

  1. Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886. Riendeau, D., Aspiotis, R., Ethier, D., Gareau, Y., Grimm, E.L., Guay, J., Guiral, S., Juteau, H., Mancini, J.A., Méthot, N., Rubin, J., Friesen, R.W. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
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