The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PTGES2  -  prostaglandin E synthase 2

Homo sapiens

Synonyms: C9orf15, FLJ14038, GBF-1, GBF1, Membrane-associated prostaglandin E synthase-2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PTGES2


High impact information on PTGES2


Biological context of PTGES2


Anatomical context of PTGES2


Associations of PTGES2 with chemical compounds

  • Microsomal prostaglandin E synthase type-2 (mPGES-2) has been crystallized with an anti-inflammatory drug indomethacin (IMN), and the complex structure has been determined at 2.6A resolution. mPGES-2 forms a dimer and is attached to lipid membrane by anchoring the N-terminal section [5].
  • Compounds 23 and 30 inhibit mPGES-1 with potencies in the low nanomolar range and with selectivities of at least 100-fold compared to their inhibition of mPGES-2, thromboxane synthase and binding affinity to FLAP [12].

Other interactions of PTGES2

  • Prostaglandin E(2) (PGE(2)) is synthesized by one of three enzymes, cytosolic prostaglandin E synthase (cPGES), microsomal PGES-1 (mPGES-1) and microsomal PGES-2 (mPGES-2) [10].

Analytical, diagnostic and therapeutic context of PTGES2

  • Western blot analysis showed mPGES-1 protein expression limited to open ulcer tissue, while mPGES-2 and cPGES immunoreactivities were seen in both open and closed ulcer tissue [1].
  • On the other hand, mPGES-2 and cytosolic PGES (cPGES) that are functionally coupled with COX-1 were upregulated after treatment with PS liposomes or LPS [7].
  • Recent gene targeting studies of mPGES-1 have revealed that this enzyme represents a novel target for anti-inflammatory and anti-cancer drugs. mPGES-2 is synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme [13].


  1. Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue. Gudis, K., Tatsuguchi, A., Wada, K., Futagami, S., Nagata, K., Hiratsuka, T., Shinji, Y., Miyake, K., Tsukui, T., Fukuda, Y., Sakamoto, C. Lab. Invest. (2005) [Pubmed]
  2. Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle. Duffy, D.M., Seachord, C.L., Dozier, B.L. Hum. Reprod. (2005) [Pubmed]
  3. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. Murakami, M., Nakashima, K., Kamei, D., Masuda, S., Ishikawa, Y., Ishii, T., Ohmiya, Y., Watanabe, K., Kudo, I. J. Biol. Chem. (2003) [Pubmed]
  4. IFN-gamma-stimulated transcriptional activation by IFN-gamma-activated transcriptional element-binding factor 1 occurs via an inducible interaction with CAAAT/enhancer-binding protein-beta. Meng, Q., Raha, A., Roy, S., Hu, J., Kalvakolanu, D.V. J. Immunol. (2005) [Pubmed]
  5. Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2). Yamada, T., Komoto, J., Watanabe, K., Ohmiya, Y., Takusagawa, F. J. Mol. Biol. (2005) [Pubmed]
  6. Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2. Watanabe, K., Ohkubo, H., Niwa, H., Tanikawa, N., Koda, N., Ito, S., Ohmiya, Y. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  7. Involvement of COX-1 and up-regulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia. Zhang, J., Fujii, S., Wu, Z., Hashioka, S., Tanaka, Y., Shiratsuchi, A., Nakanishi, Y., Nakanishi, H. J. Neuroimmunol. (2006) [Pubmed]
  8. Development of monoclonal antibodies against GBF1 and their use in studying its functions. Roy, S.K., Hu, J., Meng, Q., Hu, J., Reddy, S.P., Kalvakolanu, D.V. J. Interferon Cytokine Res. (2005) [Pubmed]
  9. Molecular cloning and tissue distribution of microsomal-1 and cytosolic prostaglandin E synthases in macaque. Parent, J., Chapdelaine, P., Fortier, M.A. Prostaglandins Other Lipid Mediat. (2005) [Pubmed]
  10. Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. Astle, S., Newton, R., Thornton, S., Vatish, M., Slater, D.M. Mol. Hum. Reprod. (2007) [Pubmed]
  11. Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2. Kino, Y., Kojima, F., Kiguchi, K., Igarashi, R., Ishizuka, B., Kawai, S. Prostaglandins Leukot. Essent. Fatty Acids (2005) [Pubmed]
  12. Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886. Riendeau, D., Aspiotis, R., Ethier, D., Gareau, Y., Grimm, E.L., Guay, J., Guiral, S., Juteau, H., Mancini, J.A., Méthot, N., Rubin, J., Friesen, R.W. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  13. Prostaglandin e synthase, a terminal enzyme for prostaglandin E2 biosynthesis. Kudo, I., Murakami, M. J. Biochem. Mol. Biol. (2005) [Pubmed]
WikiGenes - Universities