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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Anti-MuSK myasthenia gravis presenting with purely ocular findings.

BACKGROUND: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described. OBJECTIVE: To report a case of ocular myasthenia due to anti-MuSK antibodies. PATIENT: A young woman with ocular myasthenia and antibodies to MuSK. RESULTS: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. CONCLUSION: Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.[1]


  1. Anti-MuSK myasthenia gravis presenting with purely ocular findings. Caress, J.B., Hunt, C.H., Batish, S.D. Arch. Neurol. (2005) [Pubmed]
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