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MeSH Review

Respiratory Muscles

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Disease relevance of Respiratory Muscles


Psychiatry related information on Respiratory Muscles


High impact information on Respiratory Muscles

  • The respiratory-muscle performance of the patients taking theophylline improved by approximately 29 percent (P less than 0.0001), as indicated by a decline in the ratio of inspiratory pleural pressure during quiet breathing to maximal pleural pressure [10].
  • In conclusion, triamcinolone induced type IIb fiber atrophy, resulting in reduced respiratory muscle strength and a leftward shift of the force-frequency curve [11].
  • We conclude that NPV as used in this study is difficult to apply and ineffective when used with the aim of resting the respiratory muscles in patients with stable COPD [12].
  • CONCLUSIONS: Selective respiratory muscle training improves respiratory muscle endurance and strength, with an enhancement of submaximal and maximal exercise capacity in patients with heart failure [13].
  • Elevated levels of lactate in brain, blood, and cerebrospinal fluid, abnormal urine organic acids, and changes in muscle respiratory chain enzymes are present but inconsistent, without identifiable mitochondrial DNA mutations or deletions [14].

Chemical compound and disease context of Respiratory Muscles


Biological context of Respiratory Muscles


Anatomical context of Respiratory Muscles


Associations of Respiratory Muscles with chemical compounds

  • By analyzing the power spectrum and the amplitude behavior of the diaphragmatic EMG (calculated from the fc and RMS, respectively), we could exclude a disturbance of neural descending pathways and respiratory muscle dysfunction as possible causal mechanisms for the impaired ventilatory response to increasing CO2 [30].
  • To manipulate O2 supply and O2 demand in locomotor and respiratory muscles, subjects performed both maximal conventional two-legged cycle ergometry (large muscle mass) and single-leg knee extensor exercise (KE, small muscle mass) while breathing room air (RA), 100% O2, and 79% helium + 21% O2 (HeO2) [31].
  • Aminophylline and respiratory muscle interaction in normal humans [32].
  • The adverse effect of long-term steroid treatment on respiratory muscle function remains controversial [33].
  • Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits [34].

Gene context of Respiratory Muscles


Analytical, diagnostic and therapeutic context of Respiratory Muscles


  1. SEPN1: associated with congenital fiber-type disproportion and insulin resistance. Clarke, N.F., Kidson, W., Quijano-Roy, S., Estournet, B., Ferreiro, A., Guicheney, P., Manson, J.I., Kornberg, A.J., Shield, L.K., North, K.N. Ann. Neurol. (2006) [Pubmed]
  2. Evidence of reduced respiratory muscle endurance in patients with heart failure. Mancini, D.M., Henson, D., LaManca, J., Levine, S. J. Am. Coll. Cardiol. (1994) [Pubmed]
  3. Variability of patient-ventilator interaction with pressure support ventilation in patients with chronic obstructive pulmonary disease. Jubran, A., Van de Graaff, W.B., Tobin, M.J. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  4. Respiratory muscle recruitment and exercise performance in eucapnic and hypercapnic severe chronic obstructive pulmonary disease. Montes de Oca, M., Celli, B.R. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  5. Effect of theophylline on diaphragmatic and other skeletal muscle function. Aubier, M. J. Allergy Clin. Immunol. (1986) [Pubmed]
  6. Adverse environmental conditions in the respiratory and medical ICU settings. Meyer, T.J., Eveloff, S.E., Bauer, M.S., Schwartz, W.A., Hill, N.S., Millman, R.P. Chest (1994) [Pubmed]
  7. Respiratory muscle aids for the prevention of pulmonary morbidity and mortality. Bach, J.R. Seminars in neurology. (1995) [Pubmed]
  8. Mechanism of hemoglobin desaturation during rapid-eye-movement sleep in normal subjects and in patients with cystic fibrosis. Muller, N.L., Francis, P.W., Gurwitz, D., Levison, H., Bryan, A.C. Am. Rev. Respir. Dis. (1980) [Pubmed]
  9. Respiratory response to partial paralysis in anesthetized dogs. Oliven, A., Deal, E.C., Kelsen, S.G., Cherniack, N.S. Journal of applied physiology: respiratory, environmental and exercise physiology. (1984) [Pubmed]
  10. A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary disease. Murciano, D., Auclair, M.H., Pariente, R., Aubier, M. N. Engl. J. Med. (1989) [Pubmed]
  11. Triamcinolone and prednisolone affect contractile properties and histopathology of rat diaphragm differently. Dekhuijzen, P.N., Gayan-Ramirez, G., de Bock, V., Dom, R., Decramer, M. J. Clin. Invest. (1993) [Pubmed]
  12. Effect of negative pressure ventilation in severe chronic obstructive pulmonary disease. Shapiro, S.H., Ernst, P., Gray-Donald, K., Martin, J.G., Wood-Dauphinee, S., Beaupré, A., Spitzer, W.O., Macklem, P.T. Lancet (1992) [Pubmed]
  13. Benefit of selective respiratory muscle training on exercise capacity in patients with chronic congestive heart failure. Mancini, D.M., Henson, D., La Manca, J., Donchez, L., Levine, S. Circulation (1995) [Pubmed]
  14. Progressive cavitating leukoencephalopathy: a novel childhood disease. Naidu, S., Bibat, G., Lin, D., Burger, P., Barker, P., Rosemberg, S., Braverman, N., Arroyo, H., Dowling, M., Hamosh, A., Kimonis, V., Blank, C., Fiumara, A., Facchini, S., Singhal, B., Moser, H., Kelley, R., DiMauro, S. Ann. Neurol. (2005) [Pubmed]
  15. Effects of emphysema on diaphragm microvascular oxygen pressure. Poole, D.C., Kindig, C.A., Behnke, B.J. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  16. Human chest wall function while awake and during halothane anesthesia. II. Carbon dioxide rebreathing. Warner, D.O., Warner, M.A. Anesthesiology (1995) [Pubmed]
  17. Polymyositis with respiratory muscle weakness requiring mechanical ventilation in a patient with metastatic thymoma treated with octreotide. Rini, B.I., Gajewski, T.F. Ann. Oncol. (1999) [Pubmed]
  18. Acid-base disturbances in acute asthma. Mountain, R.D., Heffner, J.E., Brackett, N.C., Sahn, S.A. Chest (1990) [Pubmed]
  19. Corticosteroid-induced myopathy and the respiratory muscles. Report of two cases. Janssens, S., Decramer, M. Chest (1989) [Pubmed]
  20. Oxidative stress and respiratory muscle dysfunction in severe chronic obstructive pulmonary disease. Barreiro, E., de la Puente, B., Minguella, J., Corominas, J.M., Serrano, S., Hussain, S.N., Gea, J. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  21. Oxygen cost of exercise hyperpnea: implications for performance. Aaron, E.A., Seow, K.C., Johnson, B.D., Dempsey, J.A. J. Appl. Physiol. (1992) [Pubmed]
  22. Exercise conditioning and cardiopulmonary fitness in cystic fibrosis. The effects of a three-month supervised running program. Orenstein, D.M., Franklin, B.A., Doershuk, C.F., Hellerstein, H.K., Germann, K.J., Horowitz, J.G., Stern, R.C. Chest (1981) [Pubmed]
  23. Relationship between impaired pulmonary diffusion and cardiopulmonary exercise capacity after heart transplantation. Ewert, R., Wensel, R., Bruch, L., Mutze, S., Bauer, U., Plauth, M., Kleber, F.X. Chest (2000) [Pubmed]
  24. Clinical effects of heliox administration for acute bronchiolitis in young infants. Cambonie, G., Milési, C., Fournier-Favre, S., Counil, F., Jaber, S., Picaud, J.C., Matecki, S. Chest (2006) [Pubmed]
  25. Fatiguing inspiratory muscle work causes reflex sympathetic activation in humans. St Croix, C.M., Morgan, B.J., Wetter, T.J., Dempsey, J.A. J. Physiol. (Lond.) (2000) [Pubmed]
  26. Protein tyrosine nitration in the ventilatory muscles: role of nitric oxide synthases. Barreiro, E., Comtois, A.S., Gea, J., Laubach, V.E., Hussain, S.N. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  27. Effect of a vecuronium-induced partial neuromuscular block on hypoxic ventilatory response. Eriksson, L.I., Sato, M., Severinghaus, J.W. Anesthesiology (1993) [Pubmed]
  28. Human chest wall function while awake and during halothane anesthesia. I. Quiet breathing. Warner, D.O., Warner, M.A., Ritman, E.L. Anesthesiology (1995) [Pubmed]
  29. Presentation and prognosis of the shrinking lung syndrome in systemic lupus erythematosus. Karim, M.Y., Miranda, L.C., Tench, C.M., Gordon, P.A., D'cruz, D.P., Khamashta, M.A., Hughes, G.R. Semin. Arthritis Rheum. (2002) [Pubmed]
  30. No effect of naloxone on ventilatory response to progressive hypercapnia in IDDM patients. Wanke, T., Abrahamian, H., Lahrmann, H., Formanek, D., Merkle, M., Auinger, M., Zwick, H., Irsigler, K. Diabetes (1993) [Pubmed]
  31. Evidence of skeletal muscle metabolic reserve during whole body exercise in patients with chronic obstructive pulmonary disease. Richardson, R.S., Sheldon, J., Poole, D.C., Hopkins, S.R., Ries, A.L., Wagner, P.D. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  32. Aminophylline and respiratory muscle interaction in normal humans. Gorini, M., Duranti, R., Misuri, G., Valenza, T., Spinelli, A., Goti, P., Gigliotti, F., Scano, G. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  33. Inspiratory muscle strength and endurance in steroid-dependent asthma. Perez, T., Becquart, L.A., Stach, B., Wallaert, B., Tonnel, A.B. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  34. Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits. Kiwull-Schöne, H.F., Teppema, L.J., Kiwull, P.J. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  35. Role of heme oxygenases in sepsis-induced diaphragmatic contractile dysfunction and oxidative stress. Barreiro, E., Comtois, A.S., Mohammed, S., Lands, L.C., Hussain, S.N. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  36. Regulation of nitric oxide production in limb and ventilatory muscles during chronic exercise training. Vassilakopoulos, T., Deckman, G., Kebbewar, M., Rallis, G., Harfouche, R., Hussain, S.N. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  37. The effect of respiratory muscle training with CO2 breathing on cellular adaptation of mdx mouse diaphragm. Matecki, S., Rivier, F., Hugon, G., Koechlin, C., Michel, A., Prefaut, C., Mornet, D., Ramonatxo, M. Neuromuscul. Disord. (2005) [Pubmed]
  38. Myosin gene expression in the respiratory muscles. Gea, J.G. Eur. Respir. J. (1997) [Pubmed]
  39. Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity. Baar, K., Song, Z., Semenkovich, C.F., Jones, T.E., Han, D.H., Nolte, L.A., Ojuka, E.O., Chen, M., Holloszy, J.O. FASEB J. (2003) [Pubmed]
  40. Respiratory muscle endurance training in chronic obstructive pulmonary disease: impact on exercise capacity, dyspnea, and quality of life. Scherer, T.A., Spengler, C.M., Owassapian, D., Imhof, E., Boutellier, U. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  41. Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Hui, D.S., Joynt, G.M., Wong, K.T., Gomersall, C.D., Li, T.S., Antonio, G., Ko, F.W., Chan, M.C., Chan, D.P., Tong, M.W., Rainer, T.H., Ahuja, A.T., Cockram, C.S., Sung, J.J. Thorax (2005) [Pubmed]
  42. Effect of aminophylline on respiratory muscle strength after upper abdominal surgery: a double blind study. Siafakas, N.M., Stoubou, A., Stathopoulou, M., Haviaras, V., Tzanakis, N., Bouros, D. Thorax (1993) [Pubmed]
  43. Diaphragmatic rest during negative pressure ventilation by pneumowrap. Assessment in normal and COPD patients. Nava, S., Ambrosino, N., Zocchi, L., Rampulla, C. Chest (1990) [Pubmed]
  44. Comparison of isocapnic hyperventilation and walking exercise training at home in pulmonary rehabilitation. Ries, A.L., Moser, K.M. Chest (1986) [Pubmed]
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