Gene Review:
MUSK - muscle, skeletal, receptor tyrosine kinase
Homo sapiens
Synonyms:
MuSK, Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific kinase receptor, Muscle-specific tyrosine-protein kinase receptor
- The agrin/muscle-specific kinase pathway: new targets for autoimmune and genetic disorders at the neuromuscular junction. Liyanage, Y., Hoch, W., Beeson, D., Vincent, A. Muscle Nerve (2002)
- Induction of myasthenia by immunization against muscle-specific kinase. Shigemoto, K., Kubo, S., Maruyama, N., Hato, N., Yamada, H., Jie, C., Kobayashi, N., Mominoki, K., Abe, Y., Ueda, N., Matsuda, S. J. Clin. Invest. (2006)
- The in vitro and in vivo phosphotyrosine map of activated MuSK. Watty, A., Neubauer, G., Dreger, M., Zimmer, M., Wilm, M., Burden, S.J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Successful treatment of MuSK antibody-positive myasthenia gravis with rituximab. Hain, B., Jordan, K., Deschauer, M., Zierz, S. Muscle Nerve (2006)
- Towards the molecular elucidation of congenital myasthenic syndromes: identification of mutations in MuSK. Chevessier, F., Faraut, B., Ravel-Chapuis, A., Richard, P., Gaudon, K., Bauché, S., Prioleau, C., Herbst, R., Goillot, E., Ioos, C., Azulay, J.P., Attarian, S., Leroy, J.P., Fournier, E., Legay, C., Schaeffer, L., Koenig, J., Fardeau, M., Eymard, B., Pouget, J., Hantaï, D. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases. (2005)
- Alpha3Na+/K+-ATPase is a neuronal receptor for agrin. Hilgenberg, L.G., Su, H., Gu, H., O'Dowd, D.K., Smith, M.A. Cell (2006)
- Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Hoch, W., McConville, J., Helms, S., Newsom-Davis, J., Melms, A., Vincent, A. Nat. Med. (2001)
- A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Forrester, W.C., Dell, M., Perens, E., Garriga, G. Nature (1999)
- Diseases of the neuromuscular junction. McConville, J., Vincent, A. Current opinion in pharmacology. (2002)
- High-dose cyclophosphamide in refractory myasthenia gravis with MuSK antibodies. Lin, P.T., Martin, B.A., Weinacker, A.B., So, Y.T. Muscle Nerve (2006)
- Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Cheusova, T., Khan, M.A., Schubert, S.W., Gavin, A.C., Buchou, T., Jacob, G., Sticht, H., Allende, J., Boldyreff, B., Brenner, H.R., Hashemolhosseini, S. Genes Dev. (2006)
- Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: required role for the MuSK ectodomain? Glass, D.J., Apel, E.D., Shah, S., Bowen, D.C., DeChiara, T.M., Stitt, T.N., Sanes, J.R., Yancopoulos, G.D. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis. Evoli, A., Tonali, P.A., Padua, L., Monaco, M.L., Scuderi, F., Batocchi, A.P., Marino, M., Bartoccioni, E. Brain (2003)
- Characterization of a muscle-specific enhancer in human MuSK promoter reveals the essential role of myogenin in controlling activity-dependent gene regulation. Tang, H., Veldman, M.B., Goldman, D. J. Biol. Chem. (2006)
- MuSK glycosylation restrains MuSK activation and acetylcholine receptor clustering. Watty, A., Burden, S.J. J. Biol. Chem. (2002)
- The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling. Herbst, R., Burden, S.J. EMBO J. (2000)
- Matrix metalloproteinase-3 removes agrin from synaptic basal lamina. VanSaun, M., Werle, M.J. J. Neurobiol. (2000)
- Rapsyn clusters and activates the synapse-specific receptor tyrosine kinase MuSK. Gillespie, S.K., Balasubramanian, S., Fung, E.T., Huganir, R.L. Neuron (1996)
- N-acetyllactosamine and the CT carbohydrate antigen mediate agrin-dependent activation of MuSK and acetylcholine receptor clustering in skeletal muscle. Parkhomovskiy, N., Kammesheidt, A., Martin, P.T. Mol. Cell. Neurosci. (2000)
- The postsynaptic submembrane machinery at the neuromuscular junction: requirement for rapsyn and the utrophin/dystrophin-associated complex. Banks, G.B., Fuhrer, C., Adams, M.E., Froehner, S.C. J. Neurocytol. (2003)
- Modulation of agrin binding and activity by the CT and related carbohydrate antigens. Xia, B., Martin, P.T. Mol. Cell. Neurosci. (2002)
- Inhibition of acetylcholine receptor function by seronegative myasthenia gravis non-IgG factor correlates with desensitisation. Spreadbury, I., Kishore, U., Beeson, D., Vincent, A. J. Neuroimmunol. (2005)
- The tetratricopeptide repeat domains of rapsyn bind directly to cytoplasmic sequences of the muscle-specific kinase. Antolik, C., Catino, D.H., Resneck, W.G., Bloch, R.J. Neuroscience (2006)
- Signaling complexes for postsynaptic differentiation. Luo, Z., Wang, Q., Dobbins, G.C., Levy, S., Xiong, W.C., Mei, L. J. Neurocytol. (2003)
- Laminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors. Marangi, P.A., Wieland, S.T., Fuhrer, C. J. Cell Biol. (2002)
- Myogenin-dependent nAChR clustering in aneural myotubes. Macpherson, P.C., Cieslak, D., Goldman, D. Mol. Cell. Neurosci. (2006)
- Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade. Tang, H., Goldman, D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Detection and characterization of MuSK antibodies in seronegative myasthenia gravis. McConville, J., Farrugia, M.E., Beeson, D., Kishore, U., Metcalfe, R., Newsom-Davis, J., Vincent, A. Ann. Neurol. (2004)
- Anti-MuSK myasthenia gravis presenting with purely ocular findings. Caress, J.B., Hunt, C.H., Batish, S.D. Arch. Neurol. (2005)
- Patterns and severity of neuromuscular transmission failure in seronegative myasthenia gravis. Nemoto, Y., Kuwabara, S., Misawa, S., Kawaguchi, N., Hattori, T., Takamori, M., Vincent, A. J. Neurol. Neurosurg. Psychiatr. (2005)
- Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis. Oh, S.J., Hatanaka, Y., Hemmi, S., Young, A.M., Scheufele, M.L., Nations, S.P., Lu, L., Claussen, G.C., Wolfe, G.I. Muscle Nerve (2006)