- Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Yang, Q., Huang, W., Jozwik, C., Lin, Y., Glasman, M., Caohuy, H., Srivastava, M., Esposito, D., Gillette, W., Hartley, J., Pollard, H.B. Proc. Natl. Acad. Sci. U.S.A. (2005)