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Chemical Compound Review

Acedoxin     4- [(3S,5R,8R,9S,10S,13R,14S,17R) -3-[(2R,4S...

Synonyms: Cardigin, Digilong, Digitrin, Myodigin, Purpurid, ...
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Disease relevance of Coramedan


Psychiatry related information on Coramedan


High impact information on Coramedan


Chemical compound and disease context of Coramedan


Biological context of Coramedan


Anatomical context of Coramedan


Associations of Coramedan with other chemical compounds


Gene context of Coramedan

  • In vitro experiments were performed with cytosolic and microsomal fractions of human liver specimens in order to investigate which enzyme forms of sulfotransferase (ST) and UDP-glucurosyltransferase (GT) are involved in the metabolism of digitoxin (dt-3) and/or its cleavage products [25].
  • Hydroxysteroid sulfotransferase and a specific UDP-glucuronosyltransferase are involved in the metabolism of digitoxin in man [25].
  • In rats, cytochrome P450 (P450) IIIA enzymes are an important determinant of digitoxin toxicity [11].
  • Based on this correlation, we correctly predicted that hamsters, which have the highest P450 IIIA activity, are extremely resistant to digitoxin toxicity [11].
  • Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin [11].

Analytical, diagnostic and therapeutic context of Coramedan


  1. Use of cholestyramine resin in digitoxin toxicity. Pieroni, R.E., Fisher, J.G. JAMA (1981) [Pubmed]
  2. The effect of chronic digitoxin administration on the contractile state of normal and nonfailing hypertrophied myocardium. Williams, J.F., Potter, R.D. J. Clin. Invest. (1975) [Pubmed]
  3. Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform. Wang, J.K., Portbury, S., Thomas, M.B., Barney, S., Ricca, D.J., Morris, D.L., Warner, D.S., Lo, D.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells. Srivastava, M., Eidelman, O., Zhang, J., Paweletz, C., Caohuy, H., Yang, Q., Jacobson, K.A., Heldman, E., Huang, W., Jozwik, C., Pollard, B.S., Pollard, H.B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Effect of physical activity on serum concentrations of digoxin and digitoxin. Grille, W., Welter, U., Johnsen, K., Kolenda, K.D., Löffler, H. Eur. J. Clin. Pharmacol. (1996) [Pubmed]
  6. Digitoxin intoxication with lethal outcome. Krappweis, J., Petereit, G., Justus, J., Altmann, E., Kirch, W. Eur. J. Med. Res. (1996) [Pubmed]
  7. Reversal of advanced digitoxin toxicity and modification of pharmacokinetics by specific antibodies and Fab fragments. Ochs, H.R., Smith, T.W. J. Clin. Invest. (1977) [Pubmed]
  8. Digitoxin elimination reduced during quinidine therapy. Garty, M., Sood, P., Rollins, D.E. Ann. Intern. Med. (1981) [Pubmed]
  9. Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Yang, Q., Huang, W., Jozwik, C., Lin, Y., Glasman, M., Caohuy, H., Srivastava, M., Esposito, D., Gillette, W., Hartley, J., Pollard, H.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Dostanic-Larson, I., Van Huysse, J.W., Lorenz, J.N., Lingrel, J.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin. Eberhart, D.C., Gemzik, B., Halvorson, M.R., Parkinson, A. Mol. Pharmacol. (1991) [Pubmed]
  12. Reductive inactivation of digitoxin by Eubacterium lentum cultures. Chandrasekaran, A., Robertson, L.W., Reuning, R.H. Appl. Environ. Microbiol. (1987) [Pubmed]
  13. Digitoxin therapy partially restores cardiac catecholamine and brain serotonin metabolism in congestive heart failure. Sole, M.J., Benedict, C.R., Versteeg, D.H., de Kloet, E.R. J. Mol. Cell. Cardiol. (1985) [Pubmed]
  14. Concentration of digoxin, methyldigoxin, digitoxin and ouabain in the myocardium of the dog following coronary occulsion. Kuhlmann, J., Kötter, V., von Leitner, E., Arbeiter, G., Schröder, R. Naunyn Schmiedebergs Arch. Pharmacol. (1975) [Pubmed]
  15. 7 beta -hydroxycardenolide glycosides. Szeleczky, Z., Sóti, M., Horváth, G., Albrecht, K. Steroids (1981) [Pubmed]
  16. Pharmacokinetics, bioavailability and serum levels of cardiac glycosides. Smith, T.W. J. Am. Coll. Cardiol. (1985) [Pubmed]
  17. Digitoxin in patients with hepatorenal insufficiency after repeated oral administration. Kirch, W., Ohnhaus, E.E., Pabst, J., Storstein, L. Eur. Heart J. (1989) [Pubmed]
  18. Disposition of digitoxin in renal failure. Vöhringer, H.F., Rietbrock, N., Spurny, P., Kuhlmann, J., Hampl, H., Baethke, R. Clin. Pharmacol. Ther. (1976) [Pubmed]
  19. Studies on digitalis. XI. Digitoxin metabolism in patients with impaired renal function. Storstein, L. Clin. Pharmacol. Ther. (1977) [Pubmed]
  20. Kinetics of digitoxin and the bis- and monodigitoxosides of digitoxigenin in normal subjects. Graves, P.E., Fenster, P.E., MacFarland, R.T., Marcus, F.I., Perrier, D. Clin. Pharmacol. Ther. (1984) [Pubmed]
  21. Effect of heparin on digitoxin protein binding. Lohman, J.J., Hooymans, P.M., Koten, M.L., Verhey, M.T., Merkus, F.W. Clin. Pharmacol. Ther. (1985) [Pubmed]
  22. Characterization of the alpha +-like Na+,K+-ATPase which mediates ouabain inhibition of adrenergic induction of N-acetyltransferase (EC activity: studies with isolated pinealocytes. González-García, C., Ceña, V., Klein, D.C. Mol. Pharmacol. (1987) [Pubmed]
  23. Effects of quinidine on pharmacokinetics and pharmacodynamics of digitoxin achieving steady-state conditions. Kuhlmann, J., Dohrmann, M., Marcin, S. Clin. Pharmacol. Ther. (1986) [Pubmed]
  24. Fluoroimmunoassay of digitoxin in serum. Al-Hakiem, M.H., Simon, M., Mahmod, S., Landon, J. Clin. Chem. (1982) [Pubmed]
  25. Hydroxysteroid sulfotransferase and a specific UDP-glucuronosyltransferase are involved in the metabolism of digitoxin in man. Schmoldt, A., Blömer, I., Johannes, A. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
  26. Pharmacokinetics of digoxin and digitoxin in patients undergoing hemodialysis. Finkelstein, F.O., Goffinet, J.A., Hendler, E.D., Lindenbaum, J. Am. J. Med. (1975) [Pubmed]
  27. Digitoxin kinetics and renal excretion in children. Larsen, A., Storstein, L. Clin. Pharmacol. Ther. (1983) [Pubmed]
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