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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Subungual verrucous carcinoma of the thumb treated by intra-arterial infusion with methotrexate.

BACKGROUND: For preservation of integrity of appearance and function in a 66-year-old male with an extremely rare case of verrucous carcinoma developing from the subungium of his right thumb, intra-arterial infusion with methotrexate was used. OBJECTIVE: To evaluate the effectiveness of arterial infusion with methotrexate in this unusual nail bed cancer. METHODS: Right brachial arterial catheterization and infusion with methotrexate (50 mg) were used every 24 hours together with simultaneous intramuscular injection of 6 mg of leucovorin every 6 hours for 10 days. RESULTS: At 4 years, 8 months after therapy, the patient was in sustained complete remission with a functionally normal right thumb. CONCLUSION: This case study suggests that intra-arterial infusion chemotherapy is a simple and effective method for thumb subungual verrucous carcinoma with the unique advantage of preservation of morphology and functional conditions. It can be considered an effective treatment option.[1]


  1. Subungual verrucous carcinoma of the thumb treated by intra-arterial infusion with methotrexate. Sheen, M.C., Sheen, Y.S., Sheu, H.M., Wong, T.W., Lee, Y.Y., Wu, C.F., Wang, Y.W., Chai, C.Y. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2005) [Pubmed]
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