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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pd-Cu bimetallic catalyzed domino cyclization of alpha-allenols followed by a coupling reaction: new sequence leading to functionalized spirolactams.

A novel regioselective metal-catalyzed spirocyclization of alpha-allenols-cross coupling (Heck, Sonogashira, and Suzuki) reaction sequence, leading to potentially bioactive spirocyclic lactam derivatives has been developed. Precursors for the tandem spirocyclization-coupling reaction, alpha-allenols 2 a-d were obtained starting from alpha-oxolactams 1 a-c via indium-mediated Barbier-type carbonyl-allenylation reaction in aqueous media by using our previously described methodologies.[1]

References

  1. Pd-Cu bimetallic catalyzed domino cyclization of alpha-allenols followed by a coupling reaction: new sequence leading to functionalized spirolactams. Alcaide, B., Almendros, P., Rodríguez-Acebes, R. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
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