Disease relevance of indium

• We examined the prevalence of osteomyelitis, the major complications and efficacies of long-term antibiotic therapy and surgery, and the performance characteristics of four diagnostic tests (roentgenography, technetium Tc 99m bone scanning, indium in 111-labeled white blood cell scanning, and magnetic resonance imaging) [1].
• Indium 111-leukocyte scanning has recently been introduced as a new method for imaging inflammatory bowel disease [2].
• Early and delayed indium 111 leukocyte imaging in Crohn's disease [3].
• Location and activity of ulcerative and Crohn's colitis by indium 111 leukocyte scan. A prospective comparison study [4].
• A prospective blinded study comparing the indium 111 leukocyte scan to barium enema, colonoscopy, or surgery or a combination of these, was carried out in 15 patients (10 with active ulcerative colitis and 5 with active Crohn's colitis) [4].

High impact information on indium

• We compared results of roentgenograms, leukocyte scans with indium In 111 oxyquinoline, and bone scans with the diagnostic criterion standards of bone histologic and culture findings [5].
• When Indium-labeled PMNs were incubated with primary monolayers of cultured human umbilical vein EC, the basal adherence was 10 +/- 1% of the PMNs at 5 min [6].
• METHODS: Applying the recently developed indium-labeled somatostatin analogue 111In-pentetreotide to 40 patients with gastroenteropancreatic neuroendocrine tumors, the diagnostic power of pentreotide-receptor scintigraphy was evaluated in comparison with conventional imaging techniques [7].
• The kinetics of fecal indium 111 excretion in patients treated with nonsteroidal antiinflammatory drugs was almost identical to that of patients with small bowel Crohn's disease [8].
• Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. A comparison with colonoscopy, histology, and fecal indium 111-granulocyte excretion [2].

Chemical compound and disease context of indium

• Myocyte cell damage after administration of doxorubicin or mitoxantrone in breast cancer patients assessed by indium 111 antimyosin monoclonal antibody studies [9].
• Evaluation of aplastic anemia with indium chloride In 111 scanning [10].
• The percent of indium excess (100 [total indium-111 activity-blood pool indium-111 activity]/blood pool indium-111 activity) within the cardiac region measured (+/- SD) 16.8 +/- 11.6% in all patients with myocardial infarction (19.1 +/- 11.2% in those with visually identified foci) compared with 0.4 +/- 4.3% in control patients (p less than 0.001) [11].
• All patients had radiologic evidence of liver disease progression and high uptake of indium 111 ((111)In) pentetreotide at scintigraphy [12].
• The test, using 50% hypertonic glucose solution labeled with radioactive Indium 113m was performed on 39 preoperative patients and 107 times on 72 patients after operation for duodenal ulcer [13].

Biological context of indium

• Application of a similar electrical potential to cells cultured on indium tin oxide surfaces had no effect on cell shape or function [14].
• Microvascular permeability was quantitatively assessed as a protein leak index by measuring the rate of extravascular accumulation of radiolabeled protein (indium 113m transferrin) normalized for vascular surface area (technetium 99m erythrocytes) [15].
• Since indium, a similar class 3A metal, has not been well studied, we examined its effects on cellular iron uptake and cellular proliferation [16].
• Therefore, modification of the gold particle surface by indium has been used to vary the active site characteristics of a suitable catalyst, and a selective decoration of gold particle faces has been observed, leaving edges free [17].
• Indium 111-labeled monoclonal antibody to cardiac myosin was examined for efficacy in the detection of cardiac graft rejection and rejection-related myocyte necrosis [18].

Anatomical context of indium

• An 8-ml bolus containing 50 mu Ci of indium 111-diethylene triamine pentaacetic acid was instilled into the cecum via a 2-mm tube, which was passed orally, and serial scintigrams were obtained over 48 h [19].
• In this report a scintigraphic technique using 2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid labeled with technetium 99m to visualize the gallbladder and its emptying and diethylenetriamine pentaacetic acid labeled with indium 111 to visualize the stomach and its emptying was used to study 43 normal subjects and 18 patients with vagotomies [20].
• Indium-labeled granulocyte accumulation was significantly less in ischemic myocardium in AICA riboside-treated compared with saline-treated dogs [21].
• Myocardial accumulation of labeled lymphocytes was quantified (indium excess, IE) with a previously described and validated technique [22].
• Single photon-emission tomography (SPECT) and indium 111-labeled monoclonal antimyosin Fab fragments were used to measure myocardial infarct size in 12 dogs, six subjected to balloon catheter-induced coronary artery occlusion for 6 hr (late reperfusion) and six subjected to occlusion with reperfusion at 2 hr (early reperfusion) [23].

Associations of indium with other chemical compounds

• We conclude that dual-isotope SPECT with indium 111-monoclonal antimyosin antibodies and thallium-201 can accurately estimate infarct size and percentage myocardium infarcted [23].
• The particle sizes lie in the range of 15-20 nm for the iron, 10-15 nm for the indium, 2.5-3.5 nm for gallium, and around 20 nm for zinc oxide [24].
• These results indicate that indium chloride in 111 is a useful agent for the delineation of erythroid cellularity within bone marrow [25].
• Growth of InP nanostructures via reaction of indium droplets with phosphide ions: synthesis of InP quantum rods and InP-TiO2 composites [26].
• Stabilization of these electron-poorer phases through electronic tuning occurs via two different structural (redox) perturbations, either by substitution of certain indium atoms in the clusters by electron-poorer lithium atoms or by the introduction of defects and disorder in the fused cluster (III) [27].

Gene context of indium

• Residence time of adoptively transferred Indium 111 (111In)-labeled D4 cells in lungs of normal and HA-Tg mice as analyzed by dual modality imaging revealed a significantly shorter transit time of 4 hours for the D4 cells upon in vivo blockade of LFA-1 [28].
• C2-ceramide (20 microM) had no effect on the killing of leukaemic cells (HL-60 and K562 cells) by monocytes treated with IFN-gamma, LPS, or both for 18 hr, with killing assessed by an 111 Indium-releasing assay [29].
• Somatostatin receptor type 2 gene expression in neuroblastoma, measured by competitive RT-PCR, is related to patient survival and to somatostatin receptor imaging by indium -111-pentetreotide [30].
• A tissue-specific inhibition of ALAD occurs in the kidney after treatment of rats with indium [31].
• Imaging studies with anti-EGF receptor MAb labeled with indium 111 (111In) demonstrated selective uptake in xenografts expressing high receptor levels [32].

Analytical, diagnostic and therapeutic context of indium

• Indium-labelled autologous platelets as diagnostic aid after renal transplantation [33].
• Estimated infarct size from indium SPECT images showed an excellent correlation with true infarct size (r = .95, SEE = 4.1 g) [23].
• All patients received 5-mCi indium 111-labeled antiferritin 2 mg intravenously and were scanned repeatedly by gamma camera [34].
• In vivo studies in athymic mice using an indium conjugate of an anti-CEA monoclonal antibody (MoAb) revealed excellent specific uptake in colorectal carcinoma xenografts [35].
• By electron microscopy, no breaks were detected in the integrity of the endothelium and no increase in indium activity over the graft was recorded after injection of 111In-labeled platelets [36].

References