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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bucillamine-induced toxic epidermal necrolysis and fixed drug eruption.

We report two cases of bucillamine-induced bullous reactions with keratinocyte necrosis. The first patient, a 27-year-old woman, developed toxic epidermal necrolysis (TEN) over her whole body after taking bucillamine 300 mg/day for seven days. The second patient, a 63-year-old woman, developed several bullous erythemas on the mucous membranes and legs after taking bucillamine for more than two years. The fixed drug eruptions were diagnosed based on a provocation test in addition to clinical and histopathologic findings. These cases highlight the importance of considering fixed drug eruption as well as TEN in the differential diagnosis of bucillamine-induced bullous drug eruption.[1]


  1. Bucillamine-induced toxic epidermal necrolysis and fixed drug eruption. Izumi, A., Katsumi, S., Kobayashi, N., Niizeki, H., Asada, H., Miyagawa, S. J. Dermatol. (2005) [Pubmed]
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