Disease relevance of Drug Eruptions

• There was no phlebitis, buttocks abscess, or drug eruptions, and treatment was better tolerated in the streptomycin and sulfisoxazole group [1].
• Balanitis as a fixed drug eruption to tetracycline [2].
• Pigmented penile lesions (fixed drug eruptions) associated with tetracycline therapy for sexually transmitted diseases [3].
• Severe erythema anulare centrifugum-like psoriatic drug eruption induced by terbinafine [4].
• The cutaneous side-effects of levamisole include non-specific and lichenoid eruptions, fixed drug eruption and, very rarely, cutaneous vasculitis [5].

High impact information on Drug Eruptions

• Fixed drug eruptions were noted with ibuprofen and naproxen, and photosensitivity was reported with sulindac and indomethacin [6].
• Fixed drug eruption from chlorphenesin carbamate [7].
• Fixed drug eruption and pseudoephedrine [8].
• Multilocalized fixed drug eruption to the antihistamine cetirizine [9].
• Successful desensitization of a fixed drug eruption caused by allopurinol [10].

Chemical compound and disease context of Drug Eruptions

• CONCLUSIONS: Lymphocytes reactive to sulfamethoxazole were detected at low frequencies in the peripheral blood of three patients with drug eruptions secondary to administration of sulfamethoxazole [11].
• Successful desensitization for treatment of a fixed drug eruption to allopurinol [12].
• Fixed drug eruption induced by mepivacaine [13].
• CONCLUSION: Serious drug eruptions associated with lamotrigine were rare [14].
• Fixed drug eruption associated with co-trimoxazole [15].

Biological context of Drug Eruptions

• CONCLUSIONS: Our results challenge several current concepts regarding drug eruptions by discarding a strong association with glutathione deficiency, slow acetylation, or active viral infections and by showing no preventive effect of corticosteroids [16].
• We describe a case in which it was due to a fixed drug eruption following the inhalation of heroin pyrolysate and methaqualone vapours [17].
• Although only 17 cases of fixed drug eruption provoked by mefenamic acid have been reported in the world literature, in a 7-day period a further three patients with fixed drug eruption due to mefenamic acid presented to the dermatology out-patient clinic of the University Hospital of Wales, Cardiff [18].
• He was given the diagnosis of drug eruption from cetirizine and hydroxyzine, which suggests that there were cross-reactions among cetirizine, hydroxyzine, and ethylenediamine [19].
• We describe a case of nonpigmenting solitary fixed drug eruption appearing on the right thigh of a 31-year-old woman in Japan. The causative drug was determined by closed patch test on postlesional skin as a Chinese traditional herbal medicine, ma huang (Ephedra Hebra), mainly containing pseudoephedrine and ephedrine [20].

Anatomical context of Drug Eruptions

• These results suggest that localized misregulated expression of ICAM-1 by the keratinocytes may be one factor that explains the preferential site-specificity characteristic of fixed drug eruptions [21].
• Fixed drug eruption of the scrotum due to methylphenidate [22].
• Unlike other drug eruptions, the increase in the CD8 expression was statistically significant, especially in the dermoepidermal junction and the upper dermis (P < 0.01) [23].

Gene context of Drug Eruptions

• The GSTM1 and GSTT1 gene polymorphisms seem to be associated with the development of drug eruption [24].
• Further studies may shed additional light on the role of GSTM1, GSTT1 and GSTP1 in drug eruption [24].
• Our results show that GSTP1 polymorphism is not a significant contributor to drug eruption risk [24].
• IL-5 levels were normal in all eight patients with drug eruptions without eosinophilia, and increased in five of the seven patients with HSS [25].
• Unlike the drug eruptions caused by antibiotics, where the expression of CD4 was dominant, CD8 was dominant in drug eruptions by STI571 [23].

Analytical, diagnostic and therapeutic context of Drug Eruptions

• The results of prick, patch, and intradermal tests were similar in both types of rash; however, the two patients with fixed drug eruption had developed a generalized eruption upon prick testing with mesna [26].
• Nonpigmenting solitary fixed drug eruption after skin testing and intra-articular injection of triamcinolone acetonide [27].
• The measures for the drug profiles were medicine type (ATC-code), mono- and polypharmacy, CYP-enzyme metabolism pattern, and medicine with a potential to induce lichenoid drug eruptions [28].
• Paracetamol-induced fixed drug eruption with positive immunofluorescence findings [29].
• These cases highlight the importance of considering fixed drug eruption as well as TEN in the differential diagnosis of bucillamine-induced bullous drug eruption [30].

References