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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.

Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.[1]


  1. A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. Glud, S.Z., Sørensen, A.B., Andrulis, M., Wang, B., Kondo, E., Jessen, R., Krenacs, L., Stelkovics, E., Wabl, M., Serfling, E., Palmetshofer, A., Pedersen, F.S. Blood (2005) [Pubmed]
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