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Gene Review

Mlv1  -  murine leukemia virus 1

Mus musculus

Synonyms: Mlv-1
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Disease relevance of Mlv1


Psychiatry related information on Mlv1

  • 334C murine leukemia virus, which induces a high incidence of lymphatic leukemias (80-90%) in susceptible mice following a long latency period, was found to cause a severe in vivo suppression of direct plaque-forming cells from the spleen, following antigenic stimulation with sheep red blood cells [5].
  • Permissiveness to Moloney Murine Leukemia Virus (MoMuLV) expression was examined during preimplantation and early postimplantation development of the mouse embryo [6].
  • Because platelet-activating factor (PAF) has been implicated in the pathogenesis of HIV-associated dementia complex, brain PAF levels were measured in LP-BM5 MuLV-infected mice [7].
  • Because 129/J mice are susceptible to experimental SLE and to infection with the BM5def murine leukemia virus (MuLV) mixture but do not develop the lymphoproliferative/ immunodeficiency disorder known as murine AIDS (MAIDS), we superimposed this infection on immunization with the 16/6 Id [8].
  • Since learning and memory performance deficits can be related to attention deficits, we assessed the effect of LP-BM5 MuLV infection on sustained attention performance using a two-choice serial reaction time task [9].

High impact information on Mlv1


Chemical compound and disease context of Mlv1


Biological context of Mlv1


Anatomical context of Mlv1


Associations of Mlv1 with chemical compounds


Physical interactions of Mlv1


Regulatory relationships of Mlv1


Other interactions of Mlv1


Analytical, diagnostic and therapeutic context of Mlv1


  1. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Schuler, W., Weiler, I.J., Schuler, A., Phillips, R.A., Rosenberg, N., Mak, T.W., Kearney, J.F., Perry, R.P., Bosma, M.J. Cell (1986) [Pubmed]
  2. Transformation mediated by the SV40 T antigens: separation of the overlapping SV40 early genes with a retroviral vector. Kriegler, M., Perez, C.F., Hardy, C., Botchan, M. Cell (1984) [Pubmed]
  3. The integrated genome of murine leukemia virus. Steffen, D., Weinberg, R.A. Cell (1978) [Pubmed]
  4. Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Corcoran, L.M., Adams, J.M., Dunn, A.R., Cory, S. Cell (1984) [Pubmed]
  5. Immunosuppression in mice after inoculation with 334C, a murine lymphatic leukemia-inducing virus. Schenk, P.J., Buffett, R.F. J. Natl. Cancer Inst. (1977) [Pubmed]
  6. Permissiveness to murine leukemia, virus expression during preimplantation and early postimplantation mouse development. Savatier, P., Morgenstern, J., Beddington, R.S. Development (1990) [Pubmed]
  7. Increased brain levels of platelet-activating factor in a murine acquired immune deficiency syndrome are NMDA receptor-mediated. Nishida, K., Markey, S.P., Kustova, Y., Morse, H.C., Skolnick, P., Basile, A.S., Sei, Y. J. Neurochem. (1996) [Pubmed]
  8. Amelioration of experimental systemic lupus erythematosus (SLE) by retrovirus infection. Mittleman, B.B., Morse, H.C., Payne, S.M., Shearer, G.M., Mozes, E. J. Clin. Immunol. (1996) [Pubmed]
  9. Effects of LP-BM5 murine leukemia virus infection on errors and response time in a two-choice serial reaction time task in C57BL/6 mice. Lee, B., Tumu, P., Paul, I.A. Brain Res. (2002) [Pubmed]
  10. Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination. Orlova, M., Yueh, A., Leung, J., Goff, S.P. Cell (2003) [Pubmed]
  11. Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. van Lohuizen, M., Verbeek, S., Krimpenfort, P., Domen, J., Saris, C., Radaszkiewicz, T., Berns, A. Cell (1989) [Pubmed]
  12. Role of endogenous retroviruses as mutagens: the hairless mutation of mice. Stoye, J.P., Fenner, S., Greenoak, G.E., Moran, C., Coffin, J.M. Cell (1988) [Pubmed]
  13. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Malynn, B.A., Blackwell, T.K., Fulop, G.M., Rathbun, G.A., Furley, A.J., Ferrier, P., Heinke, L.B., Phillips, R.A., Yancopoulos, G.D., Alt, F.W. Cell (1988) [Pubmed]
  14. Inhibition of in vitro Friend murine leukemia virus infection of lipopolysaccharide-activated B-cells with concanavalin A. Bowen, D.L., Isaak, D.D., Cerny, J. J. Natl. Cancer Inst. (1979) [Pubmed]
  15. Hematopoietic stem cells in Friend murine leukemia virus-infected mice undergoing chemotherapy: remission and relapse of erythropoietin-independent erythropoiesis induced by hydroxyurea. Seidel, H.J., Opitz, U. J. Natl. Cancer Inst. (1979) [Pubmed]
  16. Effect of ethidium bromide on transplanted virus-induced tumor cells. Richardson, V.J., Vodinelich, L., Wilson, A., Potter, C.W. J. Natl. Cancer Inst. (1976) [Pubmed]
  17. Detection of a recombinant murine leukemia virus-related glycoprotein on virus-negative thymoma cells. Fischinger, P.J., Thiel, H.J., Ihle, J.N., Lee, J.C., Elder, J.H. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  18. Expression of human factor IX in rat capillary endothelial cells: toward somatic gene therapy for hemophilia B. Yao, S.N., Wilson, J.M., Nabel, E.G., Kurachi, S., Hachiya, H.L., Kurachi, K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  19. Genetic interactions in induction of endogenous murine leukemia virus from low leukemic mice. McCubrey, J., Risser, R. Cell (1982) [Pubmed]
  20. Identification of mouse chromosomes required for murine leukemia virus replication. Gazdar, A.F., Oie, H., Lalley, P., Moss, W.W., Minna, J.D. Cell (1977) [Pubmed]
  21. The mouse c-abl locus: molecular cloning and characterization. Wang, J.Y., Ledley, F., Goff, S., Lee, R., Groner, Y., Baltimore, D. Cell (1984) [Pubmed]
  22. Germline integration of moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death. Jaenisch, R., Harbers, K., Schnieke, A., Löhler, J., Chumakov, I., Jähner, D., Grotkopp, D., Hoffmann, E. Cell (1983) [Pubmed]
  23. Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cuypers, H.T., Selten, G., Quint, W., Zijlstra, M., Maandag, E.R., Boelens, W., van Wezenbeek, P., Melief, C., Berns, A. Cell (1984) [Pubmed]
  24. Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Alt, F.W., Enea, V., Bothwell, A.L., Baltimore, D. Cell (1980) [Pubmed]
  25. The effect of interferon on de novo infection of Moloney murine leukemia virus. Wong, P.K., Yuen, P.H., MacLeod, R., Chang, E.H., Myers, M.W., Friedman, R.M. Cell (1977) [Pubmed]
  26. Immunocytochemical detection of a murine leukemia virus-related nuclear antigen in mouse oocytes and early embryos. Pikó, L. Cell (1977) [Pubmed]
  27. Hemolytic anemia and erythroleukemia, two distinct pathogenic effects of Friend MuLV: mapping of the effects to different regions of the viral genome. Sitbon, M., Sola, B., Evans, L., Nishio, J., Hayes, S.F., Nathanson, K., Garon, C.F., Chesebro, B. Cell (1986) [Pubmed]
  28. Independent mechanisms involved in suppression of the Moloney leukemia virus genome during differentiation of murine teratocarcinoma cells. Niwa, O., Yokota, Y., Ishida, H., Sugahara, T. Cell (1983) [Pubmed]
  29. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Like, A.A., Rossini, A.A. Science (1976) [Pubmed]
  30. Relation of GIX antigen of thymocytes to envelope glycoprotein of murine leukemia virus. Obata, Y., Ikeda, H., Stockert, E., Boyse, E.A. J. Exp. Med. (1975) [Pubmed]
  31. Expression of murine leukemia virus envelope glycoprotein gp69/71 on mouse thymocytes. Evidence for two structural variants distinguished by presence vs. absence of GIX antigen. Tung, J.S., Fleissner, E., Vitetta, E.S., Boyse, E.A. J. Exp. Med. (1975) [Pubmed]
  32. A versatile and potentially general approach to the targeting of specific cell types by retroviruses: application to the infection of human cells by means of major histocompatibility complex class I and class II antigens by mouse ecotropic murine leukemia virus-derived viruses. Roux, P., Jeanteur, P., Piechaczyk, M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  33. Footprints on the viral DNA ends in moloney murine leukemia virus preintegration complexes reflect a specific association with integrase. Wei, S.Q., Mizuuchi, K., Craigie, R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  34. Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus. Ott, D.E., Coren, L.V., Copeland, T.D., Kane, B.P., Johnson, D.G., Sowder, R.C., Yoshinaka, Y., Oroszlan, S., Arthur, L.O., Henderson, L.E. J. Virol. (1998) [Pubmed]
  35. Replication of a Moloney murine leukemia virus mutant lacking the ELP binding site. Coulombe, J., Dubé, M., Gray, D.A. Virology (1994) [Pubmed]
  36. Amphotropic murine leukemia virus is preferentially attached to cholesterol-rich microdomains after binding to mouse fibroblasts. Beer, C., Pedersen, L. Virol. J. (2006) [Pubmed]
  37. Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice. Scheijen, B., Jonkers, J., Acton, D., Berns, A. J. Virol. (1997) [Pubmed]
  38. Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus. Tsichlis, P.N., Lee, J.S., Bear, S.E., Lazo, P.A., Patriotis, C., Gustafson, E., Shinton, S., Jenkins, N.A., Copeland, N.G., Huebner, K. J. Virol. (1990) [Pubmed]
  39. Stability of AML1 (core) site enhancer mutations in T lymphomas induced by attenuated SL3-3 murine leukemia virus mutants. Amtoft, H.W., Sørensen, A.B., Bareil, C., Schmidt, J., Luz, A., Pedersen, F.S. J. Virol. (1997) [Pubmed]
  40. Moloney murine leukemia virus activates NF-kappa B. Pak, J., Faller, D.V. J. Virol. (1996) [Pubmed]
  41. N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas. van Lohuizen, M., Breuer, M., Berns, A. EMBO J. (1989) [Pubmed]
  42. Allelism and linkage studies of murine leukemia virus activation genes in low leukemic strains of mice. McCubrey, J., Risser, R. J. Exp. Med. (1982) [Pubmed]
  43. Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Tsuruyama, T., Nakamura, T., Jin, G., Ozeki, M., Yamada, Y., Hiai, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  44. Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis. Schmidt, M., Nazarov, V., Stevens, L., Watson, R., Wolff, L. Mol. Cell. Biol. (2000) [Pubmed]
  45. Genetic mapping of a cellular DNA region involved in induction of thymic lymphomas (Mlvi-1) to mouse chromosome 15. Kozak, C.A., Strauss, P.G., Tsichlis, P.N. Mol. Cell. Biol. (1985) [Pubmed]
  46. Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning. Nielsen, A.L., Pallisgaard, N., Pedersen, F.S., Jørgensen, P. Mol. Cell. Biol. (1992) [Pubmed]
  47. T-cell lymphoma induction by radiation leukemia virus in athymic nude mice. Ricciardi-Castagnoli, P., Lieberman, M., Finn, O., Kaplan, H.S. J. Exp. Med. (1978) [Pubmed]
  48. Relationship of infectious murine leukemia virus and virus-related antigens in genetic crosses between AKR and the Fv-1 compatible strain C57L. Ikeda, H., Rowe, W.P., Boyse, E.A., Stockert, E., Sato, H., Jacobs, S. J. Exp. Med. (1976) [Pubmed]
  49. Characterization of mouse mammary tumor viruses from primary tumor cell cultures. II. Biochemical and biophysical studies. Kimball, P.C., Michalides, R., Colcher, D., Schlom, J. J. Natl. Cancer Inst. (1976) [Pubmed]
  50. Transient virus expression during murine leukemia induction by X-irradiation. Haas, M. J. Natl. Cancer Inst. (1977) [Pubmed]
  51. Rescue of a transforming virus from a spontaneous nonproducing osteosarcoma in BALB/c mice. Bentvelzen, P., Nooter, K., Deys, B.F. J. Natl. Cancer Inst. (1978) [Pubmed]
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