Prednicarbate (Dermatop): profile of a corticosteroid.
BACKGROUND: Topical steroids have been a popular choice for treating various cutaneous disorders; however, the potential for significant local and systemic adverse events, like skin atrophy and hypothalamic-pituitary-adrenal (HPA) axis suppression, has limited their use. OBJECTIVE: This article reviews the topical steroid prednicarbate through its mechanism of action, clinical efficacy, and adverse events profile. METHODS: Published literature containing the word "prednicarbate" was examined and summarized. RESULTS: Prednicarbate is a nonhalogenated, double-ester derivative of prednisolone that has been used in the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses such as atopic dermatitis. It has a favorable benefit-risk ratio, low skin atrophy potential, and high anti-inflammatory action. CONCLUSION: These characteristics make prednicarbate an ideal alternative agent for children, elderly patients, and those who require long-term intermittent treatment.[1]References
- Prednicarbate (Dermatop): profile of a corticosteroid. Gupta, A.K., Chow, M. Journal of cutaneous medicine and surgery. (2004) [Pubmed]
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