Disease relevance of Hoe 777

• Prednicarbate and its vehicle, however, do not reverse irritant dermatitis [1].
• Topical glucocorticoids such as betamethasone 17-valerate (BMV) and prednicarbate (PC) are an important therapeutic option in atopic eczema [2].
• Allergic contact dermatitis from prednicarbate [3].
• Silver textiles reduced the severity of the pruritus (p = 0.031); silver-free textiles (n.s.) and prednicarbate (n.s.) were less effective [4].
• Allergic contact dermatitis to prednicarbate presenting as lupus erythematosus [5].

High impact information on Hoe 777

• CONCLUSIONS: Prednicarbate and hydrocortisone aceponate are intermediate potent glucocorticoids that are superior to betamethasone 17-valerate because of the improved benefit/risk ratio [1].
• Fibroblast migration was dosage dependently inhibited from 10(-9) M to 10(-5) M for desoximetasone, while incubation with prednicarbate did not cause a reduction of the chemotactic response at concentrations lower than 10(-7) M [6].
• To reduce the risk of dermal atrophy, we aimed at BMV incorporation into solid lipid nanoparticles (SLN) for epidermal targeting using various lipids and emulsifiers corresponding to previous work on PC [2].
• PURPOSE: To investigate pharmacokinetic differences between the nonhalogenated double ester prednicarbate (PC) and the fluorinated monoester betamethasone 17-valerate (BM17V) their metabolism in human keratinocytes and fibroblasts as well as their permeation and biotransformation in reconstructed epidermis and excised human skin was compared [7].
• PURPOSE: Evaluation of skin layer-specific prednicarbate (PC) biotransformation, possibly explaining the improved benefit/risk ratio of this topical corticosteroid in atopic dermatitis (1,2) [8].

Chemical compound and disease context of Hoe 777

• Small reduction of capsaicin-induced neurogenic inflammation in human forearm skin by the glucocorticoid prednicarbate [9].
• RESULTS: Prednicarbate is a nonhalogenated, double-ester derivative of prednisolone that has been used in the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses such as atopic dermatitis [10].

Biological context of Hoe 777

• Studies on the pharmacokinetics and metabolism of prednicarbate after cutaneous and oral administration [11].

Anatomical context of Hoe 777

• In transfected COS-7 cells we related the transcriptional potencies of PC, its metabolites and conventional GC to their receptor binding properties [12].

Gene context of Hoe 777

• The remarkable anti-inflammatory effects of PC are in strong contrast to its reported low glucocorticoid receptor (GR) binding affinity [12].
• Interestingly, bovine serum albumin (BSA) commonly used in receptor media in permeation studies to facilitate solubility of highly lipophilic substances strongly inhibited the metabolism of topically applied prednicarbate in reconstructed epidermis [13].

Analytical, diagnostic and therapeutic context of Hoe 777

• To obtain a further highly desired increase by drug targeting to viable epidermis, PC was incorporated into solid lipid nanoparticles (SLN) [14].
• Comparison of various pharmaceutical preparations of prednicarbate after repeated topical administration to the skin of rats [15].
• For treatment and skin care these patients were given a topical glucocorticoid preparation (prednicarbate) and the corresponding emollient [16].

References