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Lara, B. et al.

Peptidoglycan precursor pools associated with MraY and FtsW deficiencies or antibiotic treatments.

Blocking peptidoglycan synthesis in Escherichia coli with moenomycin or vancomycin led to the accumulation of UDP-MurNAc-pentapeptide and of its immediate upstream precursors, whereas with cephaloridine or penicillin G the pool of UDP-MurNAc-pentapeptide decreased. With MraY and FtsW deficiencies the decrease of UDP-MurNAc-pentapeptide was accompanied by an increase of the upstream nucleotide precursors and the appearance of UDP-MurNAc-tetrapeptide.[1]

References

Peptidoglycan precursor pools associated with MraY and FtsW deficiencies or antibiotic treatments. Lara, B., Mengin-Lecreulx, D., Ayala, J.A., van Heijenoort, J. FEMS Microbiol. Lett. (2005) [Pubmed]

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