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Chemical Compound Review

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Disease relevance of UDP-MurNAc-tetrapeptide


High impact information on UDP-MurNAc-tetrapeptide

  • In the corresponding mutants, UDP-MurNAc-pentapeptide was extensively converted to UDP-MurNAc-tetrapeptide following hydrolysis of d-Ala(5), thereby providing the substrate of Ldt(fm) [3].
  • Upstream from the structural genes for these proteins were vanW(G) with unknown function and vanY(G) containing a frameshift mutation which resulted in premature termination of the encoded protein and accounted for the lack of UDP-MurNAc-tetrapeptide in the cytoplasm [4].
  • Analysis of peptidoglycan precursors in both strains indicated that UDP-MurNAc-tetrapeptide and UDP-MurNAc-pentapeptide[D-Ser] were synthesized in E. gallinarum SC1 only in the presence of vancomycin (4 microg/ml), whereas the "resistance" precursors accumulated in the cytoplasm of BM4174 cells under both inducing and noninducing conditions [5].
  • Although the active site of VanY(D) was external to the membrane, UDP-MurNAc-tetrapeptide was produced internally, probably from UDP-MurNAc-pentadepsipeptide [6].
  • With MraY and FtsW deficiencies the decrease of UDP-MurNAc-pentapeptide was accompanied by an increase of the upstream nucleotide precursors and the appearance of UDP-MurNAc-tetrapeptide [7].


  1. Inhibition of peptidoglycan biosynthesis by ramoplanin. Somner, E.A., Reynolds, P.E. Antimicrob. Agents Chemother. (1990) [Pubmed]
  2. Purification of a nocardicin A-sensitive LD-carboxypeptidase from Escherichia coli by affinity chromatography. Ursinus, A., Steinhaus, H., Höltje, J.V. J. Bacteriol. (1992) [Pubmed]
  3. Novel Mechanism of Resistance to Glycopeptide Antibiotics in Enterococcus faecium. Cremniter, J., Mainardi, J.L., Josseaume, N., Quincampoix, J.C., Dubost, L., Hugonnet, J.E., Marie, A., Gutmann, L., Rice, L.B., Arthur, M. J. Biol. Chem. (2006) [Pubmed]
  4. The vanG glycopeptide resistance operon from Enterococcus faecalis revisited. Depardieu, F., Bonora, M.G., Reynolds, P.E., Courvalin, P. Mol. Microbiol. (2003) [Pubmed]
  5. Transcriptional analysis of the vanC cluster from Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance. Panesso, D., Abadía-Patiño, L., Vanegas, N., Reynolds, P.E., Courvalin, P., Arias, C.A. Antimicrob. Agents Chemother. (2005) [Pubmed]
  6. The VanY(D) DD-carboxypeptidase of Enterococcus faecium BM4339 is a penicillin-binding protein. Reynolds, P.E., Ambur, O.H., Casadewall, B., Courvalin, P. Microbiology (Reading, Engl.) (2001) [Pubmed]
  7. Peptidoglycan precursor pools associated with MraY and FtsW deficiencies or antibiotic treatments. Lara, B., Mengin-Lecreulx, D., Ayala, J.A., van Heijenoort, J. FEMS Microbiol. Lett. (2005) [Pubmed]
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