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Chemical Compound Review

AC1NURHV     (7S)-3-[(3S)-3-[[(2R)-2- acetamido-4-[(2R...

Synonyms: 16124-22-4, Udp-N-acetylmuramic acid pentapeptide, Udp-N-acetylmuramic acid pentapeptides
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Disease relevance of UDP-murnac-pentapeptide

  • Recombinant LvFemX exhibits Km values of 42 and 15 microm for UDP-MurNAc pentapeptide and Escherichia coli Ala-tRNAAla, respectively, and exhibited a kcat value of 660 min-1 [1].
  • The nascent peptidoglycan synthesizing system from Gaffkya homari utilized the dansylated nucleotide with a Vmax/Km of 0.05 and a Vmax of 0.10 times the values for UDP-MurNAc-pentapeptide [2].
  • We previously reported the identification of the femX gene from Lactobacillus viridescens and recombinant expression of active FemX (LvFemX) that catalyzes the transfer of l-Ala from Ala-tRNAAla to the epsilon-amino group of l-lysine of UDP-MurNAc pentapeptide (Hegde, S. S., and Shrader, T. E. (2001) J. Biol. Chem. 276, 6998-7003) [1].
  • Phospho-MurNAc-pentapeptide translocase in membrane fragments from Staphylococcus aureus Copenhagen catalyzed the transfer of phospho-MurNAc-Ala-DGlu-Lys(Nepsilon-Dns)-DAla-DAla to undecaprenyl phosphate with a Vmax/Km of 3.8 and a Vmax of 1.6 times the values for UDP-MurNAc-pentapeptide [2].
  • However, the expression of low-level resistance to vancomycin was observed only when both genes were cloned in E. faecalis JH2-2 together with the vanXYc gene from Enterococcus gallinarum BM4174 which encodes a d,d-peptidase which eliminates preferentially the high affinity vancomycin UDP-MurNAc-pentapeptide [D-Ala] precursors produced by the host [3].

High impact information on UDP-murnac-pentapeptide


Chemical compound and disease context of UDP-murnac-pentapeptide


Biological context of UDP-murnac-pentapeptide


Associations of UDP-murnac-pentapeptide with other chemical compounds


Gene context of UDP-murnac-pentapeptide


Analytical, diagnostic and therapeutic context of UDP-murnac-pentapeptide


  1. Kinetic and mechanistic characterization of recombinant Lactobacillus viridescens FemX (UDP-N-acetylmuramoyl pentapeptide-lysine N6-alanyltransferase). Hegde, S.S., Blanchard, J.S. J. Biol. Chem. (2003) [Pubmed]
  2. Fluorescent substrate for nascent peptidoglycan synthesis. Uridine diphosphate-N-acetylmuramyl-(Nepsilon-5-dimethylaminonaphthalene-1-sulfonyl)pentapeptide. Weppner, W.A., Neuhaus, F.C. J. Biol. Chem. (1977) [Pubmed]
  3. Mechanism of intrinsic resistance to vancomycin in Clostridium innocuum NCIB 10674. David, V., Bozdogan, B., Mainardi, J.L., Legrand, R., Gutmann, L., Leclercq, R. J. Bacteriol. (2004) [Pubmed]
  4. Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria. Jacobs, C., Frère, J.M., Normark, S. Cell (1997) [Pubmed]
  5. Novel Mechanism of Resistance to Glycopeptide Antibiotics in Enterococcus faecium. Cremniter, J., Mainardi, J.L., Josseaume, N., Quincampoix, J.C., Dubost, L., Hugonnet, J.E., Marie, A., Gutmann, L., Rice, L.B., Arthur, M. J. Biol. Chem. (2006) [Pubmed]
  6. High level oxacillin and vancomycin resistance and altered cell wall composition in Staphylococcus aureus carrying the staphylococcal mecA and the enterococcal vanA gene complex. Severin, A., Tabei, K., Tenover, F., Chung, M., Clarke, N., Tomasz, A. J. Biol. Chem. (2004) [Pubmed]
  7. Nucleotide sequence of the murF gene encoding the UDP-MurNAc-pentapeptide synthetase of Escherichia coli. Parquet, C., Flouret, B., Mengin-Lecreulx, D., van Heijenoort, J. Nucleic Acids Res. (1989) [Pubmed]
  8. Membrane intermediates in the peptidoglycan metabolism of Escherichia coli: possible roles of PBP 1b and PBP 3. van Heijenoort, Y., Gómez, M., Derrien, M., Ayala, J., van Heijenoort, J. J. Bacteriol. (1992) [Pubmed]
  9. In situ assay for identifying inhibitors of bacterial transglycosylase. Branstrom, A.A., Midha, S., Goldman, R.C. FEMS Microbiol. Lett. (2000) [Pubmed]
  10. Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition. Biarrotte-Sorin, S., Maillard, A.P., Delettré, J., Sougakoff, W., Arthur, M., Mayer, C. Structure (Camb.) (2004) [Pubmed]
  11. Involvement of the relA gene product and feedback inhibition in the regulation of DUP-N-acetylmuramyl-peptide synthesis in Escherichia coli. Ishiguro, E.E., Ramey, W.D. J. Bacteriol. (1978) [Pubmed]
  12. Role of the murein precursor UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala in repression of beta-lactamase induction in cell division mutants. Uehara, T., Park, J.T. J. Bacteriol. (2002) [Pubmed]
  13. Structure-based site-directed mutagenesis of the UDP-MurNAc-pentapeptide-binding cavity of the FemX alanyl transferase from Weissella viridescens. Maillard, A.P., Biarrotte-Sorin, S., Villet, R., Mesnage, S., Bouhss, A., Sougakoff, W., Mayer, C., Arthur, M. J. Bacteriol. (2005) [Pubmed]
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