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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mice deficient in microtubule-associated protein MAP1B show a distinct behavioral phenotype and altered retina function.

We investigated mice deficient for the microtubule-associated protein MAP1B, a cytoskeletal element highly expressed in the developing nervous system, for altered performance in behavior, learning, and memory. Using the multiple T-maze, the open field and the Morris water maze we found that mice homozygous for a deletion of the MAP1B gene demonstrate impaired locomotor activity most likely correlated to a lack of physical endurance in general. In contrast, there were no significant differences in cognitive function and memory retention. In addition, we performed electroretinography and observed a reduction of the a-wave amplitude in response to single flash, white light stimulation. Taken together, these data provide further evidence for an important role of MAP1B in synaptic neurotransmission.[1]

References

  1. Mice deficient in microtubule-associated protein MAP1B show a distinct behavioral phenotype and altered retina function. Pangratz-Fuehrer, S., Bubna-Littitz, H., Propst, F., Reitsamer, H. Behav. Brain Res. (2005) [Pubmed]
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