Disease relevance of Electroretinography

• By electroretinography, b-wave amplitude was reduced by 75% to 83% at 1 to 4 days after ischemia in wild-type mice versus 48% to 51% in AQP4-null CD1 mice [1].
• Duchenne/Becker muscular dystrophy: correlation of phenotype by electroretinography with sites of dystrophin mutations [2].
• Intravitreal methotrexate, combined with fluorouracil and dexamethasone, showed no evidence of drug toxicity as determined by electroretinography and histopathologic examination [3].
• METHODS: Eleven patients with typical aniridia and fully characterized PAX6 mutations underwent electroretinography [4].
• The purpose of this paper was to provide evidence for the reintroduction of simultaneously performed fluorescein angiography and electroretinography in the detection of diabetic retinopathy [5].

High impact information on Electroretinography

• Rod function, as measured by electroretinography, is abolished in Rpe65-/- mice, although cone function remains [6].
• Dystrophin expression in the human retina is required for normal function as defined by electroretinography [7].
• We observed no significant visual loss in treated abcr(-/-) mice by electroretinography [8].
• Both a homozygote and heterozygote with this RK mutation had recovery phase abnormalities of rod-isolated photoresponses by electroretinography (ERG); photoactivation was normal [9].
• A subset of families with autosomal dominant retinitis pigmentosa (RP) display reduced penetrance with some asymptomatic gene carriers showing no retinal abnormalities by ophthalmic examination or by electroretinography [10].

Chemical compound and disease context of Electroretinography

• In addition, we examined the hypothesis that nitric oxide and hydroxyl radicals were involved in the IPC protective phenomenon.Retinal ischemia was produced for 60 min in ketamine/xylazine-anesthetized Sprague-Dawley rats, and recovery was measured using electroretinography [11].
• Results of slit-lamp examinations, ophthalmoscopy, intraocular pressure, electroretinography, and light electron microscopy all remained normal throughout the three-month course of the experiment, demonstrating the lack of ocular toxicity of triamcinolone acetonide in the rabbit [12].
• We delineated the dose- and time-dependent retinal toxicity of cefepime (BMY-28142), a new third generation cephalosporin, using electroretinography in pigmented rabbit eyes [13].
• A vitrectomy infusion solution containing 32 micrograms/ml (reported in trimethoprim concentration) produced no toxicity, as demonstrated either by electroretinography or histology [14].

Biological context of Electroretinography

• In this study, we assessed visual fields, visual evoked potentials (VEPs), and electroretinography (ERG) in children treated with vigabatrin [15].
• The clinical features of these patients were determined by visual acuity, slit lamp biomicroscopy, electroretinography, fluorescein angiography, and kinetic visual field testing [16].
• The pathogenesis of infection resulting from intravitreal injection of 10(2) CFU of either a clinical ocular isolate of B. cereus producing hemolysin BL (HBL+) or an isogenic mutant in this trait (HBL-) was assessed bacteriologically and by slit lamp biomicroscopy, electroretinography, histology, and inflammatory cell enumeration [17].
• Dark-adapted electroretinography or dark adaptation testing should be done to establish the presence of abnormal rod function, and serum levels of vitamin A or carotene should be obtained to identify the cause [18].
• This consisted of best-corrected visual acuity, color vision testing, static central visual field testing, fundoscopy, electroretinography, and fluorescein angiography, when indicated [19].

Anatomical context of Electroretinography

• Adult mice with induced expression of Ang1 ubiquitously, or specifically in the retina, appeared normal and had no identifiable changes in retinal or choroidal blood vessels or in retinal function as assessed by electroretinography [20].
• The reduction in b-wave amplitudes by electroretinography were well correlated with the degree of photoreceptor degeneration, but not outer-segment dysplasia in these different rds mutants [21].
• METHODS: The LED was evaluated by comparing its effectiveness with that of cool white fluorescent light (CWF) in suppressing pineal gland melatonin content and maintaining normal retinal physiology, as evaluated by use of electroretinography (ERG), and morphology [22].
• (Two readings reflect Medelec readings before and after computer adjustments.) This study demonstrates by electroretinography significant retinal ischaemia in the presence of normal fluorescein angiography in patients with proven carotid artery disease [23].

Associations of Electroretinography with chemical compounds

• Fundus photography, fluorescein angiography, and electroretinography were used to evaluate retinal anatomy and physiology in mice lacking Sema4A [24].
• Neither electroretinography nor histopathology indicated any adverse effects of the canthaxanthin-induced retinal inclusions seen in this study [25].
• At 7 days after exposure to light electroretinography (ERG) showed that minocycline significantly preserved the amplitudes of dark-adapted a- and b-wave and light-adapted b-wave, which were all significantly reduced after exposure to light [26].
• Twelve rabbits were administered intravitreal injections of carboplatin in one eye, after which they underwent serial electroretinography [27].
• Ophthalmoscopy, electroretinography (ERG), retina and carotenoid analysis were performed as previously reported [28].

Gene context of Electroretinography

• However, with either the G160D or P247R mutation, electroretinography detected abnormal function of the inner retina, where VSX1 is expressed [29].
• Electroretinography (ERG) was used to evaluate the functional state of the retina and to determine the role of the Mitf gene in visual function [30].
• Mice lacking AQP1 have reduced IOP and impaired corneal transparency after swelling, and mice lacking AQP4 have reduced light-evoked potentials by electroretinography [31].
• METHODS: The TIMP3 gene was analyzed in family members, and 4 mutation-positive patients were studied using psychophysics and electroretinography [32].
• Dystrophin is present in the outer plexiform layer of the retina and is required for normal retinal function as measured by electroretinography [33].

Analytical, diagnostic and therapeutic context of Electroretinography

• METHODS: A nonrandomly selected cohort of 8 previous and 18 current vigabatrin users and a reference cohort of 8 never vigabatrin-treated patients with epilepsy receiving other antiepilepsy drugs (AED) underwent electro-oculography (EOG), electroretinography (ERG), and automated static threshold perimetry [34].
• Intravitreal moxifloxacin: retinal safety study with electroretinography and histopathology in animal models [35].
• METHODS: Wild-type mice and PDEG:(tm1)/+ mice were subjected to electroretinography (ERG) 1 hour after exposure to one of three treatments: 1) no drug, 2) an intraperitoneal injection of sildenafil at 2 times the equivalent maximal daily recommended dosage for humans, or 3) 10 times this dosage [36].
• Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction [37].
• We examined a white-eyed strain of the norpA mutant (norpA;cn bw) and white (w)norpA+ controls using microspectrophotometry (MSP), electron microscopy (EM), and electroretinography (ERG) [38].

References