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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Differences in Antioxidative Response of Rat Hippocampus and Cortex after Exposure to Clinical Dose of {gamma}-Rays.

Ionizing radiation increases intracellular production of reactive oxygen species, which can damage cell structure and function. The brain is particularly vulnerable to oxidative injury, and in an area-dependent manner. In order to elucidate differences in enzymatic antioxidative response of rat hippocampus and cortex, we measured activities of CuZnSOD, MnSOD, and CAT in those two brain regions, isolated 1 h and 24 h after exposure to 2 Gy of gamma-rays. Our results indicate that lower MnSOD activities and inducibility, found in the hippocampus, are probably some of the main reasons for the particularly great oxidative vulnerability of this brain region.[1]

References

  1. Differences in Antioxidative Response of Rat Hippocampus and Cortex after Exposure to Clinical Dose of {gamma}-Rays. Todorovic, A., Kasapovic, J., Pejic, S., Stojiljkovic, V., Pajovic, S.B. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
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