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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The connections between C75 and obesity drug-target pathways.

Obesity and its attendant disorders, such as Type II diabetes, have reached epidemic proportions in the USA, and their prevalence is increasing globally. C75 is a small-molecule inhibitor of fatty acid synthase ( FAS) and a stimulator of carnitine palmitoyl 1 activity, which causes profound weight loss in mice. Although C75 is not a compound that is destined for human drug development, it has provided two potential pathways to target in obesity therapy: fatty acid synthesis and fatty acid oxidation. In this article, we discuss the latest data challenging the relationship between fatty acid synthase inhibition and C75-induced anorexia.[1]


  1. The connections between C75 and obesity drug-target pathways. Kuhajda, F.P., Landree, L.E., Ronnett, G.V. Trends Pharmacol. Sci. (2005) [Pubmed]
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